| Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study. | |
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MedLine Citation:
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PMID: 21054230 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: This pilot study evaluates the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima-medial thickness (IMT), and clinical, metabolic, and atherogenic inflammatory markers in 79 subjects with heterozygous familial hypercholesterolemia (hFH). All subjects were free of previous vascular disease manifestations. Methods: The body mass index (in kilograms per square meter), plasma lipids, glucose, C-reactive protein, and white blood cell counts were evaluated. After full-mouth periodontal examinations, patients were categorized into the severe periodontitis group (SPG) or non-severe periodontitis group (NSPG). Results: The SPG showed significantly higher values of cholesterol-year scores, triglycerides, glucose, PWV, IMT, and diastolic blood pressure (DBP) (P ≤0.05) than the NSPG. After adjustment for traditional risk factors for atherosclerosis, only the association between severe periodontitis and DBP (odds ratio: 3.1; 95% CI: 1.1 to 8.5; P = 0.03) was confirmed. Conclusion: In individuals with hFH, severe periodontitis was associated with a higher DBP, which suggests that severe periodontitis, itself, may contribute to the increased cardiovascular risk profile in this population. |
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Authors:
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Carolina L Z Vieira; Patricia R Cury; Marcio H Miname; Lilton R Martinez; Luiz A Bortolotto; Isabela B Giuliano; Raul D Santos; Bruno Caramelli |
Publication Detail:
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Type: Journal Article Date: 2010-11-08 |
Journal Detail:
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Title: Journal of periodontology Volume: 82 ISSN: 1943-3670 ISO Abbreviation: J. Periodontol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 683-8 Citation Subset: D; IM |
Affiliation:
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Heart Institute, Medical School, University of São Paulo, São Paulo, SP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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