| Severe laryngeal dysplasia in a 20-year-old nonsmoker treated with CO2 laser excision: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 20860544 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: We present the unusual case of a 20-year-old female nonsmoker with severe laryngeal dysplasia managed with endoscopic CO(2) laser resection with frozen-section analysis. We use her case as a platform for discussion of the current evidence surrounding laryngeal dysplasia, particularly etiology and the use of lasers in management. BACKGROUND DATA: Laryngeal dysplasia represents a series of progressive epithelial changes that can eventually lead to invasive laryngeal carcinoma. Typically, most patients are male, in their 50s or 60s, and are smokers; to our knowledge our patient represents the youngest reported case of this condition in a woman with no established risk factors. We discuss the implications of this on her subsequent management with the CO(2) laser. METHODS: With the help of intraoperative photographs, we describe our excisional technique with the CO(2) laser, model 315M Superpulse class 4 (Irradia AB, Stockholm, Sweden) at a 6-W continuous power setting. RESULTS: At 6 months after surgery, our patient remains disease free with good voice quality. CONCLUSIONS: Our patient appears to defy all the usual etiologic stereotypes that usually govern the development of laryngeal dysplasia. CO(2) laser excision plus intraoperative frozen-section analysis remains a safe and reliable method for the treatment of laryngeal dysplasia; the reassurance of histologically clear margins minimizes the extent of radical laser excision necessary and provides good functional results. We provide a comprehensive overview of the current literature on laryngeal dysplasia etiology and treatment, particularly the use of lasers in management. |
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Authors:
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Lyndsay Fraser; Gerard Kelly; Kenneth MacLennan; Zvoru G G Makura |
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Publication Detail:
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Type: Journal Article Date: 2010-09-23 |
Journal Detail:
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Title: Photomedicine and laser surgery Volume: 28 Suppl 2 ISSN: 1557-8550 ISO Abbreviation: Photomed Laser Surg Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101222340 Medline TA: Photomed Laser Surg Country: United States |
Other Details:
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Languages: eng Pagination: S115-9 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Pinderfields General Hospital, Aberford Road, Wakefield, England. LyndsayFraser@doctors.org.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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