Document Detail

Severe Kawasaki disease in infants: two fatal cases.
MedLine Citation:
PMID:  10978937     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease is a systemic vasculitis that manifests itself in many ways. Infants may present as atypical cases and commonly experience severe inflammatory changes. The two cases that are presented here highlight unusual severity and pathology. Patient 1 was a three-month-old infant with atypical Kawasaki disease who developed gangrenous lesions, and coronary and extracoronary artery aneurysms. Multiorgan failure ensued with diffuse cardiac and extracardiac aneurysms and thromboses at autopsy. Patient 2 was a five-month-old infant with Kawasaki disease, cholangitis and peripheral gangrene. Severe coronary artery aneurysms developed and he died following a myocardial infarction, despite multiple doses of intravenous immunoglobulin, acetylsalicylic acid (ASA) and corticosteroids. There is a higher occurrence of atypical disease and more severe vasculitis in infants with Kawasaki disease. Pathological changes are described, including coronary and extracardiac lesions. Patient 1 shows extensive peripheral gangrene and widespread aneurysms, and patient 2 illustrates severe cardiac complications with diffuse organ inflammation. Therapies including intravenous immunoglobulin, ASA, corticosteroids and antithrombotics are reviewed.
J L Brenner; T Jadavji; A Pinto; C Trevenen; D Patton
Related Documents :
10086577 - Reminiscences of vasilii i. kolesov.
14579987 - Current perspectives on statins.
9066187 - Prognosis of coronary arterial lesions in kawasaki disease treated without intravenous ...
19761987 - Identification of unexpected nonatherosclerotic cardiovascular disease with coronary ct...
305767 - Technical considerations in saphenous vein bypass grafts to the right coronary artery.
11054227 - The impact of isolated lesser saphenous vein system incompetence on clinical signs and ...
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  16     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-28     Completed Date:  2000-09-28     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1017-23     Citation Subset:  IM    
Alberta Children's Hospital, Calgary, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aneurysm / etiology,  pathology
Arm / pathology
Fatal Outcome
Leg / pathology
Liver / pathology
Mucocutaneous Lymph Node Syndrome / complications,  diagnosis*,  pathology
Myocardium / pathology
Erratum In:
Can J Cardiol 2000 Oct;16(10):1206

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reversible pulmonary hypertension in POEMS syndrome--another etiology of triggered pulmonary vasculo...
Next Document:  Right ventricular aneurysm caused by acute myocarditis.