| Severe Kawasaki disease in infants: two fatal cases. | |
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MedLine Citation:
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PMID: 10978937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kawasaki disease is a systemic vasculitis that manifests itself in many ways. Infants may present as atypical cases and commonly experience severe inflammatory changes. The two cases that are presented here highlight unusual severity and pathology. Patient 1 was a three-month-old infant with atypical Kawasaki disease who developed gangrenous lesions, and coronary and extracoronary artery aneurysms. Multiorgan failure ensued with diffuse cardiac and extracardiac aneurysms and thromboses at autopsy. Patient 2 was a five-month-old infant with Kawasaki disease, cholangitis and peripheral gangrene. Severe coronary artery aneurysms developed and he died following a myocardial infarction, despite multiple doses of intravenous immunoglobulin, acetylsalicylic acid (ASA) and corticosteroids. There is a higher occurrence of atypical disease and more severe vasculitis in infants with Kawasaki disease. Pathological changes are described, including coronary and extracardiac lesions. Patient 1 shows extensive peripheral gangrene and widespread aneurysms, and patient 2 illustrates severe cardiac complications with diffuse organ inflammation. Therapies including intravenous immunoglobulin, ASA, corticosteroids and antithrombotics are reviewed. |
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Authors:
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J L Brenner; T Jadavji; A Pinto; C Trevenen; D Patton |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 16 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-09-28 Completed Date: 2000-09-28 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1017-23 Citation Subset: IM |
Affiliation:
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Alberta Children's Hospital, Calgary, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aneurysm
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etiology,
pathology Arm / pathology Fatal Outcome Female Gangrene Humans Infant Leg / pathology Liver / pathology Male Mucocutaneous Lymph Node Syndrome / complications, diagnosis*, pathology Myocardium / pathology |
| Comments/Corrections | |
Erratum In:
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Can J Cardiol 2000 Oct;16(10):1206 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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