Document Detail

Severe infections in HIV-exposed uninfected infants: clinical evidence of immunodeficiency.
MedLine Citation:
PMID:  19602487     Owner:  NLM     Status:  MEDLINE    
We describe the clinical and basic immunological findings of eight HIV-exposed uninfected infants hospitalized with serious infectious morbidity and referred for immunological evaluation. The median age at presentation was 5.5 (1.5-15) months. Infections included Pneumocystis jiroveci pneumonia (three), cytomegalovirus colitis with perforation (one), Pseudomonas sepsis (two), hemorrhagic varicella (one) and Group A streptococcal meningitis and endocarditis (one). Five required intensive care, four for assisted ventilation and one for post-surgical care. Follow-up to 36 months suggested resolution of a transient immunodeficiency in two infants, one of whom had CD4 and the other B-cell depletion. Further studies are indicated in HIV-exposed uninfected infants.
A L Slogrove; M F Cotton; M M Esser
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Publication Detail:
Type:  Journal Article     Date:  2009-07-14
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  56     ISSN:  1465-3664     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-01     Completed Date:  2010-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Tygerberg Children's Hospital and Stellenbosch University, Department of Paediatrics and Child Health, Tygerberg, 7505 Western Cape, South Africa.
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MeSH Terms
Follow-Up Studies
HIV Infections* / transmission
Immunocompromised Host*
Infection / immunology*
Length of Stay
Pneumocystis jirovecii / isolation & purification
Pneumonia, Pneumocystis / diagnosis
Retrospective Studies
Risk Factors

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