Document Detail

Severe Congenital Toxoplasmosis in the United States: Clinical and Serologic Findings in Untreated Infants.
MedLine Citation:
PMID:  21956696     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Congenital toxoplasmosis can cause significant neurologic manifestations and other untoward sequelae. METHODS:: The Palo Alto Medical Foundation Toxoplasma Serology Laboratory database was searched for data on infants 0 to 180 days old, in whom congenital toxoplasmosis had been confirmed and who had been tested for Toxoplasma gondii-specific immunoglobulin G (IgG), IgM, and IgA antibodies, between 1991 and 2005. Their clinical findings were confirmed at the National Collaborative Chicago-based Congenital Toxoplasmosis Study center. We reviewed available clinical data and laboratory profiles of 164 infants with congenital toxoplasmosis whose mothers had not been treated for the parasite during gestation. RESULTS:: One or more severe clinical manifestations of congenital toxoplasmosis were reported in 84% of the infants and included eye disease (92.2%), brain calcifications (79.6%), and hydrocephalus (67.7%). In 61.6% of the infants, eye disease, brain calcifications, and hydrocephalus were present concurrently. T. gondii-specific IgM, IgA, and IgE antibodies were demonstrable in 86.6%, 77.4%, and 40.2% of the infants, respectively. Testing for IgM and IgA antibodies increased the sensitivity of making the diagnosis of congenital toxoplasmosis to 93% compared with testing for IgM or IgA individually. IgM and IgA antibodies were still present in 43.9% of infants diagnosed between 1 and 6 months of life. CONCLUSIONS:: Our study reveals that severe clinical signs of congenital toxoplasmosis including hydrocephalus, eye disease, or intracranial calcifications occurred in 85% infants whose sera were referred to our reference Toxoplasma Serology Laboratory during a period of 15 years. Laboratory tests, including serologic and polymerase chain reaction tests, were critical for diagnosis in the infants. Our results contrast remarkably with those of European investigators who rarely observe severe clinical signs in infants with congenital toxoplasmosis.
Tudor Rares Olariu; Jack S Remington; Rima McLeod; Ambereen Alam; Jose G Montoya
Related Documents :
8129366 - Airway compression by vascular anomalies in infants and neonates.
15017476 - The morbidity of the 34- to 35-week gestation: should we reexamine the paradigm?
22770106 - Effects of antenatal corticosteroids on neonatal outcomes in very-low-birth-weight pret...
21719396 - Respiratory symptoms in preterm infants: burden of disease in the first year of life.
12497216 - Microvascularization of the female urethra in fetuses, neonates and infants.
19421336 - Infant smiling dynamics and perceived positive emotion.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-27
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the *Toxoplasma Serology Laboratory, Palo Alto Medical Foundation, Palo Alto, CA; †Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA; ‡Department of Medicine, University of Chicago School of Medicine, Chicago, IL; §Toxoplasmosis Center, University of Chicago Medical Center, Chicago, IL; and ¶Department of Pediatrics, University of Chicago School of Medicine, Chicago, IL.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration.
Next Document:  Evaluation of a robotic technique for transrectal MRI-guided prostate biopsies.