| Severe congenital malaria acquired in utero. | |
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MedLine Citation:
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PMID: 20348499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vertical transmission of Plasmodium falciparum is under-recognized and usually associated with asymptomatic low-level parasitemia at birth. We report symptomatic congenital malaria presenting as a neonatal sepsis syndrome. The presence at birth of a high asexual parasitemia, gametocytemia, and splenomegaly indicated in utero rather than intrapartum transmission. The neonate was successfully treated with intravenous artesunate followed by oral dihydroartemisinin-piperaquine, without apparent adverse effects. |
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Authors:
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Jeanne R Poespoprodjo; Afdal Hasanuddin; Wendelina Fobia; Paulus Sugiarto; Enny Kenangalem; Daniel A Lampah; Emiliana Tjitra; Ric N Price; Nicholas M Anstey |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 82 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-04-22 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 563-5 Citation Subset: AIM; IM |
Affiliation:
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District Health Authority, Timika, Papua, Indonesia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antimalarials / therapeutic use Artemisinins / therapeutic use Female Humans Infant, Newborn Infectious Disease Transmission, Vertical Malaria, Falciparum / congenital*, drug therapy, transmission* Pregnancy Quinolines / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Artemisinins; 0/Quinolines; 4085-31-8/piperaquine; 71939-50-9/dihydroquinghaosu; 83507-69-1/artesunate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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