| Severe CPT-11-induced diarrhea in presence of FK-506 following liver transplantation for hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 11911319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The treatment of malignancies in transplanted patients has become an emerging issue. The anticancer agent CPT-11 is hydrolysed to the active metabolite SN-38 and many drugs interact with its metabolism and toxicity. PATIENT AND METHODS: We studied the clinical and pharmacological interactions between CPT-11 and FK506 in a liver transplant patient. Serial plasma samples of FK506, CPT-11, SN-38 and SN-38 glucuronide were assayed by high-performance liquid chromatography. RESULTS: While no CPT-11 toxicity was observed pre-operatively, several post-operative cycles of CPT-11 were complicated with severe diarrhea. No change in FK506 plasma concentrations was noted in the presence of CPT-11 but the pharmacokinetics of CPT-11 was altered in the presence of FK506. SN-38 glucuronidation was reduced for up to 12 hours following CPT-11 infusion. This increase in plasmatic exposure to unbound SN-38 might account for diarrhea. CONCLUSION: The starting dose of CPT-11 should be reduced in FK506-treated liver transplant patients. |
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Authors:
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J M Gornet; F Lokiec; J C Duclos-Vallee; D Azoulay; F Goldwasser |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 21 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2001 Nov-Dec |
Date Detail:
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Created Date: 2002-03-25 Completed Date: 2002-04-19 Revised Date: 2007-09-25 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 4203-6 Citation Subset: IM |
Affiliation:
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Service de Cancérologie, Hôpital Paul Brousse, AP-HP, Villejuif, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents, Phytogenic / adverse effects*, blood, pharmacokinetics Camptothecin / adverse effects*, analogs & derivatives*, blood, pharmacokinetics Diarrhea / chemically induced* Drug Interactions Glucuronides / blood, pharmacokinetics Humans Liver Transplantation* Tacrolimus / adverse effects*, blood, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/7-ethyl-10-hydroxycamptothecin glucuronide; 0/Antineoplastic Agents, Phytogenic; 0/Glucuronides; 100286-90-6/irinotecan; 109581-93-3/Tacrolimus; 7689-03-4/Camptothecin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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