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Severe Acute Pancreatitis During Pregnancy: Eleven Years Experience from a Surgical Intensive Care Unit.
MedLine Citation:
PMID:  21735079     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Acute pancreatitis during pregnancy is a rare and dangerous disease. This study attempts to present a comprehensive analysis of severe acute pancreatitis (SAP) during pregnancy and to identify the factors associated with poor outcomes. METHODS: This study was a retrospective review of the medical records of SAP patients during pregnancy consecutively admitted into the Research Institute of General Surgery from 1999 to 2010. RESULTS: Information was collected on presentation, management, and outcome. Eighteen patients were identified to have been diagnosed with SAP during pregnancy. Eleven patients (61.1%) were nulliparous; most attacks (88.9%) occurred during the third trimester. There were seven cases with preterm labor, six with fetal losses, and no maternal death. The etiology was biliary disease in seven patients (38.9%), hypertriglyceridemia in five patients (27.8%), both biliary and hypertriglyceridemia in four patients (22.2%), and idiopathic in two patients (11.1%). Patients with failure in more than one (≥2) organ were more likely to result in fetal loss (OR = 25, P = 0.016). CONCLUSIONS: SAP during pregnancy is predominantly biliary in etiology, but a significant proportion is caused by hypertriglyceridemia. Patients with failure in at least two organs result in relatively worse fetal outcomes.
Authors:
Yanxia Geng; Weiqin Li; Liqun Sun; Zhihui Tong; Ning Li; Jieshou Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-7
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  -     ISSN:  1573-2568     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Intensive Care Unit, Department of Surgery, Jinling Hospital, School of Medicine, Nanjing University, 305 Zhong Shan East Road, 210002, Nanjing, China.
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