Document Detail

Several synthetic progestins with different potencies adversely affect reproduction of fish.
MedLine Citation:
PMID:  23360115     Owner:  NLM     Status:  Publisher    
Synthetic progestins are widely used as a component in both contraceptives and in hormone replacement therapy (HRT), both on their own and in combination with EE2. Their presence in the environment is now established in wastewater effluent and river water and this has led to concerns regarding their potential effects on aquatic organisms living in these waters. We carried out in vivo experiments to determine the potencies of four different synthetic progestins on the reproductive capabilities of the fathead minnow (Pimephales promelas). We then performed a series of in vitro assays to try and determine the reason for the effects seen in the in vivo experiments. In the first experiment, fathead minnow exposed to a single concentration of 100ng/L of either Levonorgestrel or Gestodene stopped spawning almost completely. The same nominal concentration of Desogestrel and Drospirenone did not affect reproduction (21d NOECs of 100ng/L). The second experiment investigated two progestins of different potency - Gestodene at 1, 10, 100ng/L and Desogestrel at 100ng/L, 1µg/L and 10µg/L. Gestodene concentrations as low as 1ng/L had significant effects on reproduction over 21d, whereas concentrations of Desogestrel at or above 1µg/L were required to significantly reduce egg production. The synthetic progestins also masculinized the female fish in a concentration-dependant manner. Results from yeast-based in vitro assays demonstrated that the progestins are all strongly androgenic, thereby explaining the masculinization effects. The results strongly suggest that synthetic progestins merit serious consideration as environmental pollutants.
Tamsin J Runnalls; Nicola Beresford; Erin Losty; Alexander P Scott; John Philip Sumpter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-29
Journal Detail:
Title:  Environmental science & technology     Volume:  -     ISSN:  1520-5851     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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