| Several mechanisms contribute to the abnormal fatty acid composition of serum phospholipids and cholesterol esters in cholestatic children with extrahepatic biliary atresia. | |
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MedLine Citation:
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PMID: 9089798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fatty acid compositions of serum phospholipids and cholesterol esters and direct bilirubinemia were determined in 11 children with cholestasis due to extrahepatic biliary atresia. The levels of the different fatty acids in these lipid classes were compared with those of 22 appropriate controls and correlations with conjugated bilirubinemia were calculated. Significant differences were found in the levels of several fatty acids in these lipid classes, some of which were related to conjugated bilirubinemia. Relationships between fatty acids in phospholipids and cholesterol esters which exist in the control group were either absent or different in the patient group. The results found are compatible with the concept that malabsorption, overflow in blood of phospholipids, which are excreted in bile in healthy individuals, and liver disease per se contribute to the deviating fatty acid compositions. They suggest that administration in the diet may be required of preformed long chain polyunsaturated fatty acids in an easily absorbable form. |
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Authors:
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E Robberecht; B Koletzko; A Christophe |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 56 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-06-20 Completed Date: 1997-06-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University Hospital, Ghent, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biliary Atresia
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blood*,
complications*,
therapy Case-Control Studies Cholestasis / blood*, etiology*, therapy Cholesterol Esters / blood*, chemistry Fatty Acids / analysis, blood* Fatty Acids, Essential / administration & dosage, blood Humans Hyperbilirubinemia / blood, etiology Infant Liver Transplantation Phospholipids / blood*, chemistry Portoenterostomy, Hepatic |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol Esters; 0/Fatty Acids; 0/Fatty Acids, Essential; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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