Document Detail

Seven-day variable-stress regime alters cortical beta-adrenoceptor binding and immunologic responses: reversal by imipramine.
MedLine Citation:
PMID:  8392733     Owner:  NLM     Status:  MEDLINE    
Rats were submitted daily to a variable stressor for 1 week with or without concurrent imipramine (IMI) administration. One day after the last injection or stressful event, binding of cortical beta-adrenoceptors was determined in all experimental groups. Another group of chronically stressed animals with or without concurrent IMI administration were sacrificed 24 h following the last stress or injection treatment, and several immunologic parameters were evaluated. Chronically stressed rats showed an enhanced number of cortical beta-adrenergic sites without changes in their affinity. This effect was not present following concurrent administration with the antidepressant. In addition, a decreased percentage of T lymphocytes and a reduced delayed-type hypersensitivity reaction was also observed in stressed animals. Both responses were no longer evident when stressed rats were previously administered IMI. A possible link between behavioral, neurochemical, and immunologic alterations due to the stress regime is discussed.
A M Basso; M Depiante-Depaoli; L Cancela; V Molina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  45     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-19     Completed Date:  1993-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-72     Citation Subset:  IM    
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
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MeSH Terms
Antibody Formation / drug effects,  physiology
B-Lymphocytes / drug effects,  physiology
Cerebral Cortex / drug effects,  metabolism*
Erythrocytes / immunology
Hypersensitivity, Delayed / immunology
Imipramine / pharmacology*
Immune System / drug effects,  physiopathology*
Immunity, Cellular / drug effects,  physiology
Leukocyte Count / drug effects
Motor Activity / drug effects,  physiology
Rats, Wistar
Receptors, Adrenergic, beta / drug effects,  metabolism*
Sheep / immunology
Stress, Psychological / immunology,  metabolism*
T-Lymphocytes / drug effects,  physiology
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 50-49-7/Imipramine

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