Document Detail

Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat.
MedLine Citation:
PMID:  8240194     Owner:  NLM     Status:  MEDLINE    
Seven men participated in a double-blind study of effects of multiple-dose oral pyridostigmine bromide (PB) on physiological responses to 4-h heat stress tests (HST's) in a hot dry environment, 42 degrees C, 20% relative humidity. Subjects underwent 2 7-d series of tests, separated by 72 h, taking 30 mg PB every 8 h in one series, and placebo in the other. Each HST began right after the 0800 dose of PB or placebo. Subjects drank ad libitum during each HST, and performed two 55-min treadmill walks at about 40% VO2max during the last 2 h. Inhibition of red cell cholinesterase at the start of exercise averaged 30.0% in subjects taking PB, and did not differ significantly among HST's with PB. PB increased sweating and evaporative water loss by about 4%, and lowered chest skin temperature during exercise by 0.7 degrees C; but it had no significant effect on rectal temperature, other skin temperatures, O2 uptake, or fluid balance. PB alone had no significant effect on heart rate (HR), but had a significant interaction with day: although PB had essentially no effect on HR in the 1st HST, its effect increased progressively so that HR during exercise in the 4th HST was 8 beats.min-1 lower with PB. Multiple-dose PB had only slight effects on responses to moderate exercise-heat stress beyond those described after single-dose PB, and we found no adverse effects of multiple-dose PB administration.
B Wenger; M D Quigley; M A Kolka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  64     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-15     Completed Date:  1993-12-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  905-11     Citation Subset:  IM; S    
U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007.
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MeSH Terms
Administration, Oral
Body Temperature / drug effects
Body Temperature Regulation / drug effects*
Cholinesterases / blood
Double-Blind Method
Erythrocytes / enzymology
Exercise Test
Heart Rate / drug effects
Hot Temperature*
Physical Exertion*
Pyridostigmine Bromide / administration & dosage,  pharmacology*
Weight Loss
Reg. No./Substance:
101-26-8/Pyridostigmine Bromide; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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