| Sevelamer carbonate increases serum bicarbonate in pediatric dialysis patients. | |
| | |
MedLine Citation:
|
PMID: 19876653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sevelamer hydrochloride (HCl), a calcium-free phosphate binder, is increasingly used due to concerns related to calcium exposure and the development of vascular calcifications. However, a common side effect of sevelamer HCl, metabolic acidosis, is particularly concerning in children, as it can contribute to poor growth. Sevelamer carbonate is now available and has been shown to increase serum bicarbonate in adult patients. We conducted a prospective single-center study of pediatric dialysis patients comparing serum bicarbonate before and 3 months after a switch from sevelamer HCl to sevelamer carbonate. Inclusion criteria were a minimum of 3 months of dialysis therapy and either a serum bicarbonate <20 mmol/L or the need for sodium bicarbonate supplementation. Ten hemodialysis and 14 peritoneal dialysis patients, aged 16 +/- 3 years, were enrolled. Whereas serum calcium and phosphorus remained unchanged, serum bicarbonate increased from 20 (17.2-22.0) to 24.5 (20.75-26) mmol/L (p < 0.001) after 3 months of sevelamer carbonate therapy. Sodium bicarbonate supplementation was stopped in all patients (n = 10), reducing the mean daily sodium intake by an average of 2.3 g per patient. These results demonstrate that sevelamer carbonate is an effective phosphate binder that improves acid-base status in pediatric dialysis patients. |
| | |
Authors:
|
Elsa Gonzalez; John Schomberg; Nimisha Amin; Isidro B Salusky; Joshua Zaritsky |
Related Documents
:
|
1680433 - Pth levels correlate with mental performance in capd. 3110693 - Silicone-induced hypercalcaemia in haemodialysis patients. 22551883 - Bioimpedance-based volume at clinical target weight is contracted in hemodialysis patie... |
Publication Detail:
|
Type: Journal Article Date: 2009-10-30 |
Journal Detail:
|
Title: Pediatric nephrology (Berlin, Germany) Volume: 25 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-21 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
|
Languages: eng Pagination: 373-5 Citation Subset: IM |
Affiliation:
|
Division of Pediatric Nephrology, Department of Pediatrics, Mattel Children's Hospital at UCLA, Box 951752, Los Angeles, CA 90095-1752, USA. elsagnt@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Chelating Agents Female Hemodialysis Solutions Humans Male Peritoneal Dialysis / adverse effects, methods* Polyamines Prospective Studies Sodium Bicarbonate / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Chelating Agents; 0/Hemodialysis Solutions; 0/Polyamines; 144-55-8/Sodium Bicarbonate; 182683-00-7/sevelamer |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case of minimal change disease in a Fabry patient.
Next Document: Bioelectrical impedance vector analysis to evaluate relative hydration status.