| Setting up an HIV screening program. | |
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MedLine Citation:
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PMID: 2520544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human immunodeficiency virus-1 (HIV-1) screening programs currently are based primarily on the detection of specific HIV-1 antibodies by the commercially available enzyme immunoassay (EIA) combined with highly specific confirmation procedures. Factors to be considered in establishing a screening program include test performance characteristics, economy, confidentiality and notification procedures, legal and regulatory issues, proficiency and quality control measures, and laboratory safety. Commercial EIA screening in conjunction with a licensed Western blot assay permits the classification of all but a few serum samples into HIV-1-positive and HIV-1-negative categories. The occasional indeterminate results often can be resolved by following a defined retesting/resampling algorithm or by using research-level test procedures that may become available for diagnostic use in the future. Although screening of patient populations with an increased risk of HIV-1 exposure will improve the predictive accuracy of an initial screening assay, confirmation testing should nonetheless be performed for all EIA reactive sera regardless of the source. Local HIV-1 screening programs that meet minimum-volume requirements can result in considerable savings and flexibility for a moderate-size institution. However, before this type of program is undertaken, numerous technical and ethical considerations need to be addressed. |
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Authors:
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A Williams; R Y Dodd |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transfusion medicine reviews Volume: 3 ISSN: 0887-7963 ISO Abbreviation: Transfus Med Rev Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1992-05-20 Completed Date: 1992-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8709027 Medline TA: Transfus Med Rev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 23-6 Citation Subset: IM; X |
Affiliation:
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American Red Cross, Jerome H. Holland Laboratory, Rockville, MD 20855. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Blotting, Western HIV Seropositivity / diagnosis* Humans Mass Screening / methods* Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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