Document Detail

Setting the stage for functional repair of spinal cord injuries: a cast of thousands.
MedLine Citation:
PMID:  15672094     Owner:  NLM     Status:  MEDLINE    
Here we review mechanisms and molecules that necessitate protection and oppose axonal growth in the injured spinal cord, representing not only a cast of villains but also a company of therapeutic targets, many of which have yet to be fully exploited. We next discuss recent progress in the fields of bridging, overcoming conduction block and rehabilitation after spinal cord injury (SCI), where several treatments in each category have entered the spotlight, and some are being tested clinically. Finally, studies that combine treatments targeting different aspects of SCI are reviewed. Although experiments applying some treatments in combination have been completed, auditions for each part in the much-sought combination therapy are ongoing, and performers must demonstrate robust anatomical regeneration and/or significant return of function in animal models before being considered for a lead role.
L M Ramer; M S Ramer; J D Steeves
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Spinal cord     Volume:  43     ISSN:  1362-4393     ISO Abbreviation:  Spinal Cord     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-03     Completed Date:  2005-04-12     Revised Date:  2011-06-06    
Medline Journal Info:
Nlm Unique ID:  9609749     Medline TA:  Spinal Cord     Country:  England    
Other Details:
Languages:  eng     Pagination:  134-61     Citation Subset:  IM    
ICORD (International Collaboration on Repair Discoveries), The University of British Columbia, Vancouver, BC, Canada.
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MeSH Terms
Nerve Regeneration / physiology*
Neuronal Plasticity
Neuroprotective Agents / therapeutic use*
Recovery of Function / physiology*
Spinal Cord / drug effects,  physiopathology,  surgery
Spinal Cord Injuries / physiopathology*,  rehabilitation*
Stem Cell Transplantation / methods*
Reg. No./Substance:
0/Neuroprotective Agents
Comment In:
Spinal Cord. 2005 Dec;43(12):746   [PMID:  16010270 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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