| Setting and resetting of epigenetic marks in malignant transformation and development. | |
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MedLine Citation:
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PMID: 20658705 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Epigenetic modifications, such as DNA methylation and post-translation modifications of histones, have been shown to play an important role in chromatin structure, promoter activity, and cellular reprogramming. Large protein complexes, such as Polycomb and trithorax, often harbor multiple activities which affect histone tail modification. Nevertheless, the mechanisms underlying the deposition of these marks, their propagation during cell replication, and the alteration on their distribution during transformation still require further study. Here we review recent data on those processes in both normal and cancer cells, and we propose that the unscheduled expression of oncogenic transcription factors causes reprogramming of normal cells into cancer stem cells. |
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Authors:
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Holger Richly; Martin Lange; Elisabeth Simboeck; Luciano Di Croce |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: BioEssays : news and reviews in molecular, cellular and developmental biology Volume: 32 ISSN: 1521-1878 ISO Abbreviation: Bioessays Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510851 Medline TA: Bioessays Country: United States |
Other Details:
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Languages: eng Pagination: 669-79 Citation Subset: IM |
Affiliation:
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Centre de Regulació Genòmica (CRG), Universitat Pompeu Fabra, Barcelona, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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