Document Detail

Setting the pace: mechanisms tying Caulobacter cell-cycle progression to macroscopic cellular events.
MedLine Citation:
PMID:  15063858     Owner:  NLM     Status:  MEDLINE    
The bacterium Caulobacter crescentus divides asymmetrically, producing daughter cells with differing polar structures, different cell fates and asymmetric regulation of the initiation of chromosome replication. Complex intracellular signaling is required to keep the organelle developmental processes at the cell poles synchronized with other cell cycle events. Two recently characterized switch mechanisms controlling cell cycle progress are triggered by relatively large-scale developmental events in the cell: the progress of the DNA replication fork and the physical compartmentalization of the cell that occurs well before division. These mechanisms invoke rapid, precisely timed and even spatially differentiated regulatory responses at important points in the cell cycle.
Patrick T McGrath; Patrick Viollier; Harley H McAdams
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in microbiology     Volume:  7     ISSN:  1369-5274     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Department of Developmental Biology, Stanford University School of Medicine, B300 Beckman Center, Stanford, CA 94305, USA.
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MeSH Terms
Caulobacter / cytology*,  genetics*
Cell Cycle / physiology*
DNA Replication / physiology*
Gene Expression Regulation, Bacterial / physiology*
Grant Support

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