Document Detail

Setting and monitoring of high-frequency jet ventilation in severe respiratory distress syndrome.
MedLine Citation:
PMID:  2676344     Owner:  NLM     Status:  MEDLINE    
High-frequency jet ventilation (HFJV) is used in respiratory distress syndrome (RDS) to avoid high airway pressures and barotrauma. This study was designed to find rational strategies to regulate oxygenation and alveolar ventilation at HFJV and to determine appropriate monitoring methods. Seven dogs were subjected to total lung lavage with saline to induce RDS. PEEP was increased at conventional intermittent positive-pressure ventilation until re-expansion was indicated by a PaO2 of 300 torr at an FIO2 of 1.0 HFJV at 4 and 15 Hz was each tried at 0 and 10 cm H2O PEEP. Intermittent low-frequency inflations were also added to HFJV at 0 PEEP. Lung expansion was maintained without circulatory depression by adjustment of minute ventilation (VE) delivered by the HFJ ventilator; external PEEP was a useful complement. PaCO2 was controlled by frequency adjustment. HFJV at 4 Hz resulted in hypocapnia; intermittent low-frequency inflations had no effect. VE monitoring, CO2 elimination monitoring, and PEEP adjustment was done with a standard ventilator during HFJV. This study illustrates that HFJV is efficient in RDS; VE and external PEEP strongly influence oxygenation and may be used to regulate this factor, and frequency affects CO2 elimination, thus suggesting a method of PaCO2 control.
B Jonson; B Lachmann
Related Documents :
18091534 - Gas exchange impairment induced by open suctioning in acute respiratory distress syndro...
378544 - A simple technique for managing a bronchopleural fistula while maintaining positive pre...
2200314 - Adverse effects of large tidal volume and low peep in canine acid aspiration.
6388214 - Lateral positioning with differential lung ventilation and unilateral peep following un...
6742154 - A new method for estimating skeletal muscle capillary pressure.
1150954 - Neuromuscular blocking drugs and heart rate changes after direct nerve stimulation and ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  17     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-01     Completed Date:  1989-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1020-4     Citation Subset:  AIM; IM    
Department of Clinical Physiology, University of Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alkalosis, Respiratory / physiopathology
Blood Gas Analysis
Bronchoalveolar Lavage Fluid / analysis
High-Frequency Jet Ventilation / methods*
Hyperventilation / physiopathology
Monitoring, Physiologic / methods*
Positive-Pressure Respiration
Respiratory Distress Syndrome, Adult / physiopathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prospective, controlled, randomized trial of naloxone infusion in early hyperdynamic septic shock.
Next Document:  Measurement of gas exchange in intensive care: laboratory and clinical validation of a new device.