Document Detail

Seton drainage and fibrin glue injection for complex anal fistulas.
MedLine Citation:
PMID:  19210300     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The study aimed to evaluate the efficacy of fibrin glue in the treatment of complex anal fistula. METHOD: Thirty consecutive patients with a complex anal fistula underwent glue instillation after an 8 week period of seton drainage. Cure was defined as complete closure of any secondary opening, absence of fistula seepage, and no abscess formation. RESULTS: The mean age of the patients (15 males) was 40.5 (range, 22.8-69.1) years. The mean duration of follow-up was 11.7 (range, 0.2-33.5) months. Complete closure of the fistula was achieved in 17 patients at 1 month but in two patients a delayed abscess occurred. At the end of follow-up, 15 (50%) patients were considered to have been cured. The success rate was no different in cases of Crohn's disease or when postoperative antibiotic therapy was given. There was, however, a significant difference in success following regional vs general anaesthesia (68.4 vs 18.2% success, P = 0.02). CONCLUSION: Fibrin glue cured 50% of our first 30 patients, and regional anaesthesia was predictive of success.
V de Parades; H Safa Far; I Etienney; J-D Zeitoun; P Atienza; P Bauer
Publication Detail:
Type:  Journal Article     Date:  2009-02-07
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  12     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-63     Citation Subset:  IM    
Proctologie médico-interventionnelle Groupe hospitalier Diaconesses - Croix Saint Simon, rue du Sergent Bauchat, Paris, France.
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MeSH Terms
Combined Modality Therapy
Fibrin Tissue Adhesive / administration & dosage*
Middle Aged
Prospective Studies
Rectal Fistula / surgery,  therapy*
Tissue Adhesives / administration & dosage*
Young Adult
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 0/Tissue Adhesives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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