Document Detail


Set-point theory and obesity.
MedLine Citation:
PMID:  21117971     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Obesity is a consequence of the complex interplay between genetics and environment. Several studies have shown that body weight is maintained at a stable range, known as the "set-point," despite the variability in energy intake and expenditure. Additionally, it has been shown that the body is more efficient protecting against weight loss during caloric deprivation compared to conditions of weight gain with overfeeding, suggesting an adaptive role of protection during periods of low food intake. Emerging evidence on bariatric surgery outcomes, particularly gastric bypass, suggests a novel role of these surgical procedures in establishing a new set-point by alterations in body weight regulatory physiology, therefore resulting in sustainable weight loss results. Continuing research is necessary to elucidate the biological mechanisms responsible for this change, which may offer new options for the global burden of obesity.
Authors:
Maria Magdalena Farias; Ada M Cuevas; Fatima Rodriguez
Publication Detail:
Type:  Journal Article     Date:  2010-11-30
Journal Detail:
Title:  Metabolic syndrome and related disorders     Volume:  9     ISSN:  1557-8518     ISO Abbreviation:  Metab Syndr Relat Disord     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150318     Medline TA:  Metab Syndr Relat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
Affiliation:
1 Department of Nutrition and Metabolism, Pontificia Universidad Catolica de Chile , Santiago, Chile .
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