| Sessile serrated adenomas strongly predispose to synchronous serrated polyps in non-syndromic patients. | |
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MedLine Citation:
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PMID: 20459568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To determine the prevalence of various colonic polyps removed during a recent 8-month period; to determine the interobserver agreement in the diagnosis of serrated polyps; and to determine if harbouring a sessile serrated adenoma (SSA) predisposes to the presence of synchronous polyps with similar histology. METHODS AND RESULTS: All polyps resected during an 8-month period at a single tertiary medical centre were analysed. We also analysed all polyps in patients with an SSA or SSA with dysplasia since 2003. SSAs accounted for 4.3% of colonic polyps removed during an 8-month period. A review of 276 serrated polyps by two pathologists revealed good interobserver agreement (kappa = 0.66). Patients with one SSA were more likely to harbour additional serrated polyps. After removal of the index SSA, 18% of their remaining polyps were SSAs, SSAs with dysplasia, and traditional serrated adenomas, contrasting with the approximately 5% prevalence of these polyps in the control population. The hyperplastic polyps in the study population were also twice as likely to occur proximal to the splenic flexure. CONCLUSIONS: These data indicate that there is a strong colonic mucosal field defect in patients with sporadic SSAs that predispose them to develop additional serrated polyps. |
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Authors:
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Rish K Pai; John Hart; Amy E Noffsinger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histopathology Volume: 56 ISSN: 1365-2559 ISO Abbreviation: Histopathology Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 581-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, The University of Chicago Medical Center, Chicago, IL, USA. rpai@path.wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
/
diagnosis,
epidemiology*,
surgery Colonic Polyps / diagnosis, epidemiology*, surgery Colorectal Neoplasms / diagnosis, epidemiology*, surgery Comorbidity Diagnosis, Differential Female Humans Illinois / epidemiology Male Middle Aged Neoplasms, Multiple Primary / diagnosis, epidemiology*, surgery Observer Variation Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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