Document Detail


Sesquiterpene lactones from Smyrnium olusatrum.
MedLine Citation:
PMID:  11454342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fruits of Smyrnium olusatrum afforded three sesquiterpene lactones, namely, 1beta,8beta-dihydroxyeudesman-3,7(11)-dien-8alpha,12-olide, 1beta,8beta-dihydroxyeudesman-4(15),7(11)-dien-8alpha,l2-olide, and 1beta,10alpha,4alpha,5beta-diepoxy-6beta-hydroxyglechoman-8alpha,12-olide. Four related known sesquiterpenes were also isolated and characterized. The structure elucidation of the isolated compounds was based primarily on 1D and 2D NMR analyses. The in vitro cytotoxicity of the extract and isolated compounds against P-388 mouse lymphoma cells will be also discussed.
Authors:
A A El-Gamal
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Phytochemistry     Volume:  57     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1197-200     Citation Subset:  IM    
Affiliation:
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt. aelgama100@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / isolation & purification,  pharmacology
Chromatography
Drug Screening Assays, Antitumor
Fruit / chemistry
Lactones / isolation & purification*,  pharmacology
Libya
Magnetic Resonance Spectroscopy
Mice
Plant Extracts / chemistry,  pharmacology
Plants, Medicinal / chemistry*
Sesquiterpenes / isolation & purification*,  pharmacology
Sesquiterpenes, Eudesmane*
Spectrophotometry, Infrared
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/1,10,4,5-diepoxy-6-hydroxyglechoman-8,12-olide; 0/1,8-dihydroxyeudesman-3,7(11)-dien-8,12-olide; 0/1beta,8beta-dihydroxy-eudesman-4(15),7(11)-dien-8alpha,l2-olide; 0/Antineoplastic Agents, Phytogenic; 0/Lactones; 0/Plant Extracts; 0/Sesquiterpenes; 0/Sesquiterpenes, Eudesmane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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