Document Detail

Sesquiterpene lactone dermatitis. Cross-sensitivity in costus-sensitized patients.
MedLine Citation:
PMID:  7352764     Owner:  NLM     Status:  MEDLINE    
Thirteen costus-sensitive patients were patch tested with 38 sesquiterpene lactones of five different classes over a two-year period. Cross-reacting agents fell into two chemical categories: (1) those that resembled the primary sensitizer, and (2) those belonging to different skeletal classes. An exocyclic methylene group conjugated to a gamma-lactone was present in both chemicals that cross-reacted and those that did not. The difference between these two groups is that cross-reacting chemicals are not highly substituted, tending to be lipophilic, while those giving negative responses all are highly substituted at the C-8/C-6 position. This functional group may hinder binding of exocyclic methylene with skin protein or the actual antigenic site with an immune receptor cell.
W L Epstein; G W Reynolds; E Rodriguez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  116     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-60     Citation Subset:  AIM; IM    
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MeSH Terms
Cross Reactions*
Dermatitis, Contact / etiology*,  immunology
Lactones / adverse effects
Patch Tests
Perfume / adverse effects*
Plant Extracts / adverse effects
Sesquiterpenes / adverse effects
Reg. No./Substance:
0/Lactones; 0/Perfume; 0/Plant Extracts; 0/Sesquiterpenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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