Document Detail


Sesamin and episesamin induce apoptosis in human lymphoid leukemia Molt 4B cells.
MedLine Citation:
PMID:  10851264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The exposure of human lymphoid leukemia Molt 4B cells to sesamin and episesamin which were isolated from unroasted sesame seed oil and identified by MS, and 1H and 13C-NMR, led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological change showing apoptotic bodies was observed in the Molt 4B cells treated with sesamin and episesamin. The fragmentations by sesamin and episesamin of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis were observed to be concentration-dependent, respectively. Moreover, the amount of the DNA fragments in the sesamin-treated cells was increased from 2 days, while that in the episesamin-treated cells was elevated at 3 days after addition of the compounds. These findings suggest that growth inhibitions by sesamin and episesamin of Molt 4B cells result from the induction of apoptosis in the cells.
Authors:
Y Miyahara; T Komiya; H Katsuzaki; K Imai; M Nakagawa; Y Ishi; H Hibasami
Related Documents :
10620704 - Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decr...
7684414 - Human cd4+ cytolytic t cells kill antigen-pulsed target t cells by induction of apoptosis.
18068114 - Nuclear localized protein-1 (nulp1) increases cell death of human osteosarcoma cells an...
16565524 - Abolition of the tapetum suicide program ruins microsporogenesis.
19076834 - An investigation of the impact of the location and timing of antigen-specific t cell di...
18692524 - Cxcl12/cxcr4 signaling promotes human thymic dendritic cell survival regulating the bcl...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  6     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-21     Completed Date:  2000-08-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Affiliation:
Kukisangyo Co. Ltd., 11 Onoue-cho, Yokkaichi-city, Mie 510-0059, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemistry,  isolation & purification,  pharmacology*
Apoptosis*
DNA Fragmentation
Dioxoles / chemistry,  isolation & purification,  pharmacology*
Humans
Leukemia, Lymphoid
Lignans / chemistry,  isolation & purification,  pharmacology*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microscopy, Fluorescence
Sesame Oil / chemistry,  isolation & purification,  pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Dioxoles; 0/Lignans; 607-80-7/sesamin; 8008-74-0/Sesame Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Molecular genetic alterations and viral presence in ophthalmic pterygium.
Next Document:  Expression of PTEN and PTEN pseudogene in endometrial carcinoma.