Document Detail

Sesame lignans modulate cholesterol metabolism in the stroke-prone spontaneously hypertensive rat.
MedLine Citation:
PMID:  9072406     Owner:  NLM     Status:  MEDLINE    
1. Effects of sesamin and episesamin (an epimer of sesamin) on lipid metabolism, in particular cholesterol metabolism, were examined in normocholesterolaemic and hypercholesterolaemic stroke-prone spontaneously hypertensive rats (SHRSP). 2. In normocholesterolaemic SHRSP fed a regular diet, both sesamin and episesamin significantly increased the concentration of serum total cholesterol, which was due to an increase of high density lipoprotein (HDL) subfraction rich in apoE (apoE-HDL). In addition, both substances effectively decreased serum very low density lipoprotein (VLDL). In the liver, only episesamin significantly decreased the activity of microsomal acyl-CoA:cholesterol acyltransferase. 3. In hypercholesterolaemic SHRSP fed a high-fat and high-cholesterol diet (HFC diet), only episesamin improved serum lipoprotein metabolism with an increase in apoA-I and a decrease in apoB. In the liver, both sesamin and episesamin significantly suppressed cholesterol accumulation. Interestingly, only episesamin significantly increased the activity of microsomal cholesterol 7alpha-hydroxylase. 4. These results indicate that sesamin may be effective in preventing cholesterol accumulation in the liver. In comparison with sesamin, episesamin may be effective in the regulation of cholesterol metabolism in the serum and liver.
H Ogawa; S Sasagawa; T Murakami; H Yoshizumi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology. Supplement     Volume:  22     ISSN:  0143-9294     ISO Abbreviation:  Clin Exp Pharmacol Physiol Suppl     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-03-25     Completed Date:  1997-03-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7611484     Medline TA:  Clin Exp Pharmacol Physiol Suppl     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  S310-2     Citation Subset:  IM    
Department of Hygiene, Kinki University School of Medicine, Osaka-Sayama, Japan.
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MeSH Terms
Anticholesteremic Agents / therapeutic use*
Apolipoproteins / blood
Blood Pressure / drug effects
Cerebrovascular Disorders / genetics,  metabolism
Cholesterol / blood,  metabolism*
Dioxoles / therapeutic use*
Hypercholesterolemia / blood,  drug therapy
Lipid Metabolism*
Lipids / blood
Rats, Inbred SHR
Sterol O-Acyltransferase / blood
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Apolipoproteins; 0/Dioxoles; 0/Lignans; 0/Lipids; 57-88-5/Cholesterol; 607-80-7/sesamin; EC O-Acyltransferase

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