Document Detail


Serum zinc concentrations in patients on maintenance hemodialysis and its relationship with anemia, parathyroid hormone concentrations and pruritus severity.
MedLine Citation:
PMID:  20587866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Zinc (Zn) deficiency has been reported in 40-78% of hemodialysis (HD) patients and may be associated with anemia and pruritus and probably limiting the expression of renal osteodystrophy. This study was designed to explore possible correlation between serum zinc concentration and anemia, intact parathyroid hormone (iPTH) concentration and pruritus severity in HD patients. During a case-control study, the serum Zn concentration of patients on maintenance HD was compared with those of the healthy controls and with the cut-off point of 70 mcg/dL as the risk of Zn deficiency. The mean serum Zn concentration in patients on maintenance HD was significantly lower than that of the control group; however, it was not different with the cut-off point of 70 microg/dL. No correlation between serum Zn concentration and hematologic indices was detected. A significant positive correlation between serum Zn concentration and erythropoietn dose was noted. No correlation was found between serum Zn concentration and PTH level or pruritus severity. In conclusion, the results of this study showed that zinc concentrations were lower in HD patients compared to controls, however, the effects of routine supplementation of zinc to control anemia, serum PTH level or pruritus severity are yet doubtful.
Authors:
Simin Dashti-Khavidaki; Hossein Khalili; Seyedeh-Maryam Vahedi; Mahboob Lessan-Pezeshki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia     Volume:  21     ISSN:  1319-2442     ISO Abbreviation:  Saudi J Kidney Dis Transpl     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9436968     Medline TA:  Saudi J Kidney Dis Transpl     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  641-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. dashtis@sina.tums.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia / blood*
Bilirubin / blood
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Parathyroid Hormone / blood*
Pruritus / epidemiology*,  physiopathology
Renal Dialysis* / adverse effects
Severity of Illness Index
Zinc / blood*,  deficiency*
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 635-65-4/Bilirubin; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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