Document Detail

Serum vitamin D and subsequent occurrence of type 2 diabetes.
MedLine Citation:
PMID:  18496468     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low vitamin D status has been suggested as a risk factor for type 2 diabetes. Although the epidemiologic evidence is scarce, 2 recent studies have suggested an association. The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts. METHODS: Two nested case-control studies, collected by the Finnish Mobile Clinic in 1973-1980, were pooled for analysis. The study populations consisted of men and women aged 40-74 years and free of diabetes at baseline. During a follow-up period of 22 years, 412 incident type 2 diabetes cases occurred, and 986 controls were selected by individual matching. Serum vitamin D (serum 25(OH)D) was determined from frozen samples, stored at baseline. Pooled estimates of the relationship between serum vitamin D concentration and type 2 diabetes incidence were calculated. RESULTS: Men had higher serum vitamin D concentrations than women and showed a reduced risk of type 2 diabetes in their highest vitamin D quartile. The relative odds between the highest and lowest quartiles was 0.28 (95% confidence interval = 0.10-0.81) in men and 1.14 (0.60-2.17) in women after adjustment for smoking, body mass index, physical activity, and education. CONCLUSIONS: The results support the hypothesis that high vitamin D status provides protection against type 2 diabetes. Residual confounding may contribute to this association.
Paul Knekt; Maarit Laaksonen; Catharina Mattila; Tommi Härkänen; Jukka Marniemi; Markku Heliövaara; Harri Rissanen; Jukka Montonen; Antti Reunanen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  19     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-09-02     Revised Date:  2009-04-17    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  666-71     Citation Subset:  IM    
National Public Health Institute, Department of Health and Functional Capacity, Mannerheimintie 166, 00300 Helsinki, Finland.
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MeSH Terms
Case-Control Studies
Diabetes Mellitus, Type 2 / blood*,  epidemiology
Finland / epidemiology
Follow-Up Studies
Life Style
Logistic Models
Middle Aged
Sex Distribution
Vitamin D / blood*
Reg. No./Substance:
1406-16-2/Vitamin D
Comment In:
Future Cardiol. 2009 Jan;5(1):15-8   [PMID:  19371198 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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