Document Detail


Serum vitamin D levels are positively associated with varicella zoster immunity in chronic dialysis patients.
MedLine Citation:
PMID:  25487609     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Uremia results in a relatively immunocompromised status, and patients under chronic dialysis have an elevated risk of developing herpes zoster (HZ). We sought to investigate the relationship between vitamin D status and immunity to varicella-zoster virus (VZV). A multicenter prevalent hemodialysis cohort was assembled between 2012 and 2013. We assayed the biochemical parameters, 25-hydroxy- (25-OH-D) and 1,25-dihydroxyvitamin D, vitamin D-binding protein levels in the sera. VZV immunity was quantitated using VZV-specific glycoprotein IgG and IgM titers. Eighty-eight patients were enrolled and their sera were analyzed. Chronic hemodialysis patients with 25-OH-D < 30 ng/ml (insufficiency or deficiency) had significantly lower VZV-IgG than those with sufficient 25-OH-D (p = 0.04). This discrepancy became more prominent if active vitamin D users alone were analyzed (p = 0.01). Generalized additive modeling showed that those with 25-OH-D higher than 27.8 ng/ml or bioavailable 25-OH-D higher than 3.88 ng/ml had significantly higher VZV-IgG levels than those with lower values. Linear regression suggested that both total and bioavailable 25-OH-D were significantly associated with higher VZV-IgG levels (p = 0.003 [total] and 0.01 [bioavailable]), whereas patients with cancer had lower VZV-IgG. Vitamin D may therefore be a potentially useful choice for raising VZV immunity in chronic dialysis patients.
Authors:
Chia-Ter Chao; Szu-Ying Lee; Wei-Shun Yang; Chung-Jen Yen; Chih-Kang Chiang; Jenq-Wen Huang; Kuan-Yu Hung
Related Documents :
10589799 - Polymorphonuclear leukocyte elastase in patients with stroke.
16490949 - Early ct findings in unknown-onset and wake-up strokes.
10945429 - Computer recording of standard tests of visual neglect in stroke patients.
25487609 - Serum vitamin d levels are positively associated with varicella zoster immunity in chro...
25458049 - The metabolic syndrome and risk of coronary artery disease in patients with chronic sch...
8266389 - Pure motor hemiparesis and sensorimotor stroke. accuracy of very early clinical diagnos...
4013729 - Alterations of auditory evoked potentials during the course of chloroquine treatment.
11434359 - Improvement of thyroid hormone profile and thyrotrophin (tsh) surge alterations in hemo...
8598029 - Hypnosis and pharmacological sedation for medically compromised patients.
Publication Detail:
Type:  Journal Article     Date:  2014-12-09
Journal Detail:
Title:  Scientific reports     Volume:  4     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2014  
Date Detail:
Created Date:  2014-12-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  7371     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic stra...
Next Document:  Evaluation of automatic neonatal brain segmentation algorithms: The NeoBrainS12 challenge.