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Serum vitamin B12 levels as indicators of disease severity and mortality of patients with acute on chronic liver failure.
MedLine Citation:
PMID:  22814196     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: We investigated the association between vitamin B12 levels and patients with Acute-on-chronic liver failure (AoCLF). In addition, we analyzed whether B12 is associated with mortality in the AoCLF patients. METHODS: One hundred and five patients with AoCLF and 44 healthy controls (HCs) were prospectively studied. In all subjects, a blood sample was collected at admission to examine liver function, renal function, international normalized ratio and B12 levels. A total of 9 clinical chemistry and biochemical variables were analyzed for possible association with outcomes by using Cox proportional hazards and multiple regression models. RESULTS: AoCLF patients had significantly higher B12 concentrations at admission compared with HCs (AoCLF patients vs HCs, median 1218pg/ml, mean 1736.2pg/ml, SD, 1294.6 vs 504pg/ml, 529.8±149.8pg/ml, P<0.001). Increased B12 concentrations were associated with increased severity of liver disease and 3-month mortality rate. Multivariate analysis demonstrated that B12 concentrations and the model for end-stage liver disease score were independent predictors for mortality (both P<0.001). CONCLUSION: B12 concentrations were significantly higher in AoCLF patients than in HCs and increased B12 were associated with increased severity of disease. Moreover, B12 concentrations are an independent predicting factor for the 3-month mortality rate in AoCLF patients.
Authors:
Weilin Mao; Jiufeng Dou; Bo Ye; Yi Zhang; Weiyi Xu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-16
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang 310003, China.
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