Document Detail


Serum vitamin B12 and folate status in patients with inflammatory bowel diseases.
MedLine Citation:
PMID:  20603044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aims of this study were to investigate the prevalence of serum vitamin B(12) and folate abnormalities in patients with inflammatory bowel diseases (IBD) and to identify risk factors associated with B12 and folate abnormalities in this entity.
METHODS: 138 patients with IBD (45 Crohn's disease and 93 ulcerative colitis) and 53 healthy subjects were enrolled into the study. Fasting serum B12 and folic acid levels were measured and clinical data regarding inflammatory bowel diseases were gathered.
RESULTS: While the mean serum B(12) concentration in CD patients was 281+/-166pg/ml, the mean serum vitamin B12 concentration in UC patients was 348+/-218pg/ml (p=0.224). The number of patients with vitamin B12 deficiency in the CD group was greater than the number of patients with UC [n=10 (22%) vs. n=4 (7.5%), p=0.014]. The number of patients (n=10, 22%) with B12 deficiency in the CD group was also greater than controls (n=4, 7.5%) (p=0.039). With regard to folate levels, the median serum folate level was 7.7+/-5.3ng/ml in CD patients, 8.6+/-8.3ng/ml in UC patients and 9.9+/-3.3ng/ml in the control group (p=n.s.). Patients with a prior ileocolonic resection had an abnormal B12 concentration compared to patients without surgery (p=0.008). In CD patients, ileal involvement was the only independent risk factor for having a low folate level.
CONCLUSION: Serum vitamin B12 and folate deficiencies are common in patients with CD compared to UC patients and controls. In CD patients, prior small intestinal surgery is an independent risk factor for having a low serum vitamin B12 level.
Authors:
Mustafa Yakut; Yusuf Ustün; Gökhan Kabaçam; Irfan Soykan
Related Documents :
7686324 - Observations of the time-course of the inflammatory response of rectal mucosa to gliadi...
18945264 - Faecal microbiota profile of crohn's disease determined by terminal restriction fragmen...
7367934 - Antibiotic-associated colitis: a persistent clinical problem.
21258184 - Significance of monitoring wt1 mrna levels of peripheral blood and bone marrow in acute...
9817414 - Cavernous sinus sampling in patients with adrenocorticotrophic hormone-dependent cushin...
9299854 - Natural and acquired inhibitors of hemostasis in selected symptomatic outpatients with ...
Publication Detail:
Type:  Journal Article     Date:  2010-06-08
Journal Detail:
Title:  European journal of internal medicine     Volume:  21     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-06     Completed Date:  2010-11-09     Revised Date:  2011-02-04    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  320-3     Citation Subset:  IM    
Affiliation:
Ankara University Medical School, Ibni Sina Hospital Department of Gastroenterology, Sihhiye, Ankara, Turkey. musyakut@gmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Case-Control Studies
Chi-Square Distribution
Child
Child, Preschool
Colitis, Ulcerative / blood,  complications,  physiopathology
Crohn Disease / blood,  complications,  physiopathology
Female
Folic Acid / blood*
Folic Acid Deficiency / blood,  complications
Humans
Infant
Inflammatory Bowel Diseases / blood*,  complications,  physiopathology
Logistic Models
Male
Middle Aged
Odds Ratio
Prevalence
Retrospective Studies
Risk Factors
Sex Factors
Statistics, Nonparametric
Vitamin B 12 / blood*
Vitamin B 12 Deficiency / blood,  complications
Young Adult
Chemical
Reg. No./Substance:
59-30-3/Folic Acid; 68-19-9/Vitamin B 12
Comments/Corrections
Comment In:
Eur J Intern Med. 2011 Feb;22(1):13-5   [PMID:  21238886 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nutritional status in patients with active inflammatory bowel disease: prevalence of malnutrition an...
Next Document:  Prevalence of irritable bowel syndrome in Italian rural and urban areas.