Document Detail


Serum vimentin methylation as a potential marker for colorectal cancer.
MedLine Citation:
PMID:  25075038     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIMS: The present study aimed to examine the feasibility of detecting vimentin (VIM) methylation in the serum of patients with colorectal cancer (CRC) and to determine the effectiveness of a relatively simple, inexpensive, and non-invasive test performed in combination with the conventional carcinoembryonic antigen analysis.
MATERIALS AND METHODS: VIM methylation in the serum DNA of 242 patients with CRC was measured by a quantitative methylation-specific polymerase chain reaction.
RESULTS: A significantly higher positive rate was obtained for VIM methylation than for carcinoembryonic antigen or carbohydrate antigen 19-9 in stage 0, I, and II patients. The combination of all three markers yielded similar sensitivity for patients with disease of stage 0: 57.1%, I: 36.1%, II: 45.2%, and III: 55.4%, whereas the sensitivity reached 85.7% for patients with stage IV disease.
CONCLUSION: VIM methylation of serum DNA may be a useful marker for the early detection of CRC.
Authors:
Atsushi Shirahata; Kenji Hibi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  34     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  4121-5     Citation Subset:  IM    
Copyright Information:
Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
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