Document Detail

Serum vaspin concentrations are decreased after exercise-induced oxidative stress.
MedLine Citation:
PMID:  20975299     Owner:  NLM     Status:  MEDLINE    
Elevated visceral adipose tissue-derived serpin (vaspin) serum concentrations are associated with impaired insulin sensitivity, but increase unexpectedly after long-term physical training. We therefore investigated the effect of an acute exercise bout and the effects of vitamin supplementation on chronic exercise effect and on serum vaspin concentrations. We measured serum vaspin and thiobarbituric acid-reactive substances (TBARS) concentrations in 80 individuals before and after a 1-hour acute exercise bout and independently in 40 healthy young men who were randomly assigned to either antioxidant (vitamin C (1,000 mg/day) and vitamin E (400 IU/day)) or to no supplementation after a standardized 4-week physical training program as a post hoc analysis. Serum vaspin concentrations significantly decreased after acute physical exercise as well as after 4 weeks of training in individuals without antioxidants. Changes in vaspin serum concentration correlate with increased TBARS serum concentrations both in response to a 1-hour exercise bout (r = -0.42, p < 0.01) and to the 4-week training (r = -0.31, p < 0.05). Interestingly, supplementation with antioxidants rather increased circulating vaspin levels in response to 4 weeks of exercise. In conclusion, vaspin serum concentrations are decreased by exercise-induced oxidative stress, but not by exercise-associated improvement in insulin sensitivity.
Andreas Oberbach; Katharina Kirsch; Stefanie Lehmann; Nadine Schlichting; Mathias Fasshauer; Kim Zarse; Michael Stumvoll; Michael Ristow; Matthias Blüher; Peter Kovacs
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-10-20
Journal Detail:
Title:  Obesity facts     Volume:  3     ISSN:  1662-4025     ISO Abbreviation:  Obes Facts     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-26     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101469429     Medline TA:  Obes Facts     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  328-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Department of Medicine, University of Leipzig, Leipzig, Germany.
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MeSH Terms
Antioxidants / therapeutic use*
Ascorbic Acid / therapeutic use
Biological Markers / blood
Blood Glucose / metabolism
Dietary Supplements*
Exercise / physiology*
Insulin / blood
Oxidative Stress / drug effects*
Reactive Oxygen Species / metabolism
Serpins / blood*
Thiobarbituric Acid Reactive Substances / metabolism
Time Factors
Treatment Outcome
Vitamin E / therapeutic use
Vitamins / therapeutic use*
Young Adult
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Blood Glucose; 0/Reactive Oxygen Species; 0/SERPINA12 protein, human; 0/Serpins; 0/Thiobarbituric Acid Reactive Substances; 0/Vitamins; 11061-68-0/Insulin; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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