| Serum vaspin concentrations are decreased after exercise-induced oxidative stress. | |
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MedLine Citation:
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PMID: 20975299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated visceral adipose tissue-derived serpin (vaspin) serum concentrations are associated with impaired insulin sensitivity, but increase unexpectedly after long-term physical training. We therefore investigated the effect of an acute exercise bout and the effects of vitamin supplementation on chronic exercise effect and on serum vaspin concentrations. We measured serum vaspin and thiobarbituric acid-reactive substances (TBARS) concentrations in 80 individuals before and after a 1-hour acute exercise bout and independently in 40 healthy young men who were randomly assigned to either antioxidant (vitamin C (1,000 mg/day) and vitamin E (400 IU/day)) or to no supplementation after a standardized 4-week physical training program as a post hoc analysis. Serum vaspin concentrations significantly decreased after acute physical exercise as well as after 4 weeks of training in individuals without antioxidants. Changes in vaspin serum concentration correlate with increased TBARS serum concentrations both in response to a 1-hour exercise bout (r = -0.42, p < 0.01) and to the 4-week training (r = -0.31, p < 0.05). Interestingly, supplementation with antioxidants rather increased circulating vaspin levels in response to 4 weeks of exercise. In conclusion, vaspin serum concentrations are decreased by exercise-induced oxidative stress, but not by exercise-associated improvement in insulin sensitivity. |
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Authors:
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Andreas Oberbach; Katharina Kirsch; Stefanie Lehmann; Nadine Schlichting; Mathias Fasshauer; Kim Zarse; Michael Stumvoll; Michael Ristow; Matthias Blüher; Peter Kovacs |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: Obesity facts Volume: 3 ISSN: 1662-4025 ISO Abbreviation: Obes Facts Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101469429 Medline TA: Obes Facts Country: Switzerland |
Other Details:
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Languages: eng Pagination: 328-31 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Medicine, University of Leipzig, Leipzig, Germany. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00683560 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / therapeutic use* Ascorbic Acid / therapeutic use Biological Markers / blood Blood Glucose / metabolism Dietary Supplements* Down-Regulation Exercise / physiology* Female Germany Humans Insulin / blood Male Oxidative Stress / drug effects* Reactive Oxygen Species / metabolism Serpins / blood* Thiobarbituric Acid Reactive Substances / metabolism Time Factors Treatment Outcome Vitamin E / therapeutic use Vitamins / therapeutic use* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Blood Glucose; 0/Reactive Oxygen Species; 0/SERPINA12 protein, human; 0/Serpins; 0/Thiobarbituric Acid Reactive Substances; 0/Vitamins; 11061-68-0/Insulin; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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