Document Detail

Serum uric acid and the risk of hypertension and chronic kidney disease.
MedLine Citation:
PMID:  24419747     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: To discuss the evolving data regarding uric acid as a potential cause of hypertension and progressive renal dysfunction and its clinical and research implications.
RECENT FINDINGS: The potential mechanisms by which uric acid could cause vasoconstriction and a progressive ateriolopathy were established in animal models between 1999 and 2004. Since then, there has been a growing interest in the topic and numerous retrospective and prospective observational studies. The preponderance of data support the hypothesis that serum uric acid is a cause or exacerbating factor of hypertension and progressive kidney disease. Over the last couple of years clinical intervention trials, including randomized controlled trials in the young have supported this mechanistic role.
SUMMARY: Current evidence supports the role of uric acid as marker and mediator of risk for both hypertension and progressive decline in renal function. Data on the impact of xanthine oxidase inhibitors or uricosurics on clinical hypertension and chronic kidney disease are suggestive but inconclusive. Considerably, more data will be required to determine if uric acid lowering therapy will become a mainstay of management in diseases other than gout and tumor lysis syndrome.
Daniel I Feig
Related Documents :
9367537 - Interaction of nitric oxide with 2-thio-5-nitrobenzoic acid: implications for the deter...
18845897 - [bmim][pf(6)] promotes the synthesis of halohydrin esters from diols using potassium ha...
11948447 - Synthesis of phosphatidylcholine with defined fatty acid in the sn-1 position by lipase...
7188947 - Acid hydrolysis of military standard formulations of diazinon.
21103417 - Esophageal sensation and esophageal hypersensitivity - overview from bench to bedside.
19198907 - Engineering metabolic systems for production of advanced fuels.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-13
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  -     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression of CXCL2 in the Serum and Cerebrospinal Fluid of Patients with HIV and Syphilis or Neuros...
Next Document:  Incidence of lymphoma associated with underlying lupus: lessons learned from observational studies.