Document Detail

Serum uric acid levels and risk of metabolic syndrome in healthy adults.
MedLine Citation:
PMID:  18463036     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the relationship between hyperuricemia and metabolic syndrome in a population of healthy subjects. METHODS: We studied 1,573 healthy adults (25 to 64 years old) in the population laboratory of the Tehran University of Medical Sciences. The study was designed according to the World Health Organization MONICA (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease) project with use of the National Cholesterol Education Program Adult Treatment Panel III criteria for metabolic syndrome. RESULTS: The crude prevalence of the metabolic syndrome was 29.9% (age-adjusted, 27.5%). The rate of metabolic syndrome significantly increased in higher quartiles of serum uric acid in both sexes but especially in women (P<.0001 versus P = .026). The bivariate correlation was significant between uric acid levels and age, total serum cholesterol, high-density lipoprotein cholesterol, triglycerides, body mass index, waist and hip circumferences, waist-to-hip ratio, and systolic and diastolic blood pressures; however, there was not a significant correlation between serum uric acid concentrations and fasting plasma glucose. CONCLUSION: These data indicate that an independent relationship exists between hyperuricemia and the metabolic syndrome. Moreover, hyperuricemia is significantly correlated with hypertriglyceridemia, hypertension, and visceral obesity. Early detection of hyperuricemia seems to be essential for prevention of the metabolic syndrome.
Pantea Ebrahimpour; Hossein Fakhrzadeh; Ramin Heshmat; Fatemeh Bandarian; Bagher Larijani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  14     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-08     Completed Date:  2008-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  298-304     Citation Subset:  IM    
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Biological Markers / blood
Cross-Sectional Studies
Hypertension / blood
Hypertriglyceridemia / blood
Hyperuricemia / blood*,  diagnosis
Mass Screening
Metabolic Syndrome X / blood*,  epidemiology*,  prevention & control
Middle Aged
Obesity / blood
Predictive Value of Tests
Risk Factors
Uric Acid / blood*
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid

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