Document Detail

Serum uric acid levels and leukocyte nitric oxide production in multiple sclerosis patients outside relapses.
MedLine Citation:
PMID:  15792819     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A number of studies found that patients with multiple sclerosis (MS) have low serum levels of uric acid. It is unclear whether this represents a primary deficit or secondary effect. Uric acid is a scavenger of peroxynitrite, which is the product of nitric oxide (NO) and superoxide. Because peripheral blood leukocyte NO production and NO metabolites in serum are raised in MS patients, associations might be expected between serum uric acid levels and peripheral NO production. METHODS: Serum levels of uric acid and NO production by peripheral blood leukocytes were measured in 60 patients with MS without a relapse in the past 3 months, and 30 age- and sex-matched healthy controls. Uric acid was determined with the uricase PAP method, and NO production was assayed by measuring nitrite concentration in supernatants of lysed leukocytes. RESULTS: Serum uric acid levels were not different between MS patients and controls. Compared to controls, patients with MS had significantly higher peripheral blood leukocytes nitrite concentrations (p<0.001). There was no correlation between leukocyte nitrite concentration and serum uric acid levels. CONCLUSIONS: Our findings suggest that in MS patients there is no primary deficit in serum uric acid. NO production by peripheral blood leukocytes is increased, but there is no association with serum uric acid levels.
Jop P Mostert; Geeta S M Ramsaransing; Dorothea J Heersema; Marco Heerings; Nadine Wilczak; Jacques De Keyser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-20
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  231     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-28     Completed Date:  2005-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Department of Neurology, Academisch Ziekenhuis Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
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MeSH Terms
Case-Control Studies
Interferon-beta / therapeutic use
Leukocytes / drug effects,  metabolism*
Middle Aged
Multiple Sclerosis / blood*,  drug therapy,  metabolism
Nitric Oxide / metabolism*
Reference Values
Statistics, Nonparametric
Uric Acid / blood*
Reg. No./Substance:
10102-43-9/Nitric Oxide; 69-93-2/Uric Acid; 77238-31-4/Interferon-beta

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