| Serum uric acid levels and its association with age-related macular degeneration (ARMD). | |
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MedLine Citation:
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PMID: 21265246 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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To investigate the possible association between serum uric acid levels, serum C-Reactive Protein (CRP), and age-related macular degeneration (ARMD). A total 232 patients of the eye department at Hospital Tuanku Ja'afar, Negeri Sembilan, Malaysia were recruited over 9 weeks. Participants were divided into ARMD (Non-Neovascular ARMD, and Neovascular ARMD) and control groups. 107 participants with non-neovascular ARMD, 6 with neovascular ARMD, and 119 controls participated in the study. The control patients had a similar average Serum Uric Acid level to the average of all patients with ARMD (P = 0.617). Control group: mean 299.19 micromol/l +/- std dev. 89.847 micromol/l. ARMD group: mean 302.53 micromol/l +/- std dev. 80.794 micromol/l. The average serum uric acid levels were higher in patients with neovascular ARMD (median = 397 mean +/- std dev = 389.67 +/- 38 micromol/l) than in the non-neovascular ARMD group (288.5 micromol/l, 297.86 +/- 80.26 micromol/l), and control group (295.5 micromol/l, 299.19 +/- 89.95 micromol/l). Comparing the standardised serum uric acid levels in the control group (Median = 0.5) against the two ARMD groups separately, there was no significant difference to the non-neovascular group (P = 0.448) but there was a difference significant to the neovascular ARMD group (P = 0.044). The neovascular and non-neovascular ARMD groups had median CRP value of 0.25 mg/l and were not significantly different. There is no association between serum uric acid levels and ARMD as a whole. There is potentially an association between serum uric acid and neovascular ARMD, an association needs to be established further. There is no association between serum CRP and ARMD. |
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Authors:
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S Subramani; S E Khor; B I Livingstone; U V Kulkarni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Medical journal of Malaysia Volume: 65 ISSN: 0300-5283 ISO Abbreviation: Med. J. Malaysia Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2011-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361547 Medline TA: Med J Malaysia Country: Malaysia |
Other Details:
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Languages: eng Pagination: 36-40 Citation Subset: IM |
Affiliation:
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Department of Medicine, Aberdeen Royal Infirmary, Aberdeen, UK. siddarth.subramani@nhs.net |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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