Document Detail


Serum uric acid, kidney volume and progression in autosomal-dominant polycystic kidney disease.
MedLine Citation:
PMID:  23222419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hyperuricemia has been implicated in the development and progression of chronic kidney disease, both in animal experiments and in clinical studies. As a potentially modifiable risk factor, we examined whether serum uric acid levels correlate with early hypertension, kidney volume and progression to end-stage renal disease (ESRD) in autosomal-dominant polycystic kidney disease (ADPKD).
METHODS: Retrospective analysis of a prospective observational study of the natural history of ADPKD, conducted at the University of Colorado between 1985 and 2005. Included are 680 ADPKD adults who provided data on blood pressure, renal volume, renal function, uric acid, age at the onset of ESRD or last known age without ESRD. Serum uric acid levels were examined as a continuous variable and as gender-specific quartiles. The main outcome of interest was age at the onset of ESRD; secondary outcomes were hypertension onset before age 30 years and total kidney volume (TKV) at the study visit.
RESULTS: Subjects with early-onset hypertension had higher age-adjusted serum uric acid levels than those with no or late-onset hypertension despite similar creatinine clearance. After adjusting for age, gender and creatinine clearance, there was a 5.8% increase in TKV and 4.1% increase in TKV/body surface area for every 1 mg/dL increase in uric acid (P = 0.007). The multivariate-adjusted Cox regression demonstrated a greater hazard ratio for ESRD for subjects in the 4th and 3rd quartiles of uric acid compared with the 1st [4.8 (2.6-8.9; P < 0.001) and 2.9 (1.6-5.3; P < 0.001)].
CONCLUSIONS: Higher serum uric acid levels are associated with earlier onset of hypertension, larger kidney volume and increased hazard for ESRD in ADPKD independent of gender, body mass index and renal function at the study visit. Randomized interventional studies will be necessary to examine whether treating hyperuricemia has a protective role in ADPKD.
Authors:
Imed Helal; Kim McFann; Berenice Reed; Xiang-Dong Yan; Robert W Schrier; Godela M Fick-Brosnahan
Related Documents :
22467059 - Analysis of individual versus group behavior of zebrafish: a model using ph sublethal e...
21063589 - Cationic and radical intermediates in the acid photorelease from aryl sulfonates and ph...
24919769 - Relationship between elevated morning blood pressure surge, uric acid, and cardiovascul...
6195009 - Axoplasmic incorporation of amino acids in a myelinated fiber exceeds that of its soma:...
21832899 - Methods to assess amino acid requirements in humans.
16419999 - Uncatalyzed reactions in the classical belousov-zhabotinsky system. 2. the malonic acid...
18568159 - Nucleic acid encoding to program self-assembly in chemical biology.
23195149 - A simple assay demonstrating the effect of rehydration on the orsellinate depside hydro...
2913289 - Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid synthesis and lipogenic enzymes...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-04
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  28     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-08-30     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  380-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Disease Progression*
Female
Humans
Hypertension / epidemiology
Hyperuricemia / epidemiology
Kidney / pathology*
Kidney Failure, Chronic / epidemiology
Male
Middle Aged
Organ Size
Polycystic Kidney, Autosomal Dominant / blood*,  complications,  pathology*
Prospective Studies
Regression Analysis
Retrospective Studies
Risk Factors
Uric Acid / blood*
Grant Support
ID/Acronym/Agency:
DK34039/DK/NIDDK NIH HHS; M01RR00051/RR/NCRR NIH HHS; M01RR00069/RR/NCRR NIH HHS; ULI RR025780/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
268B43MJ25/Uric Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Factors associated with suboptimal initiation of dialysis despite early nephrologist referral.
Next Document:  Generation of mice derived from induced pluripotent stem cells.