Document Detail


Serum uric acid does not predict cardiovascular or all-cause mortality in type 2 diabetes: the Fremantle Diabetes Study.
MedLine Citation:
PMID:  20349345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS/HYPOTHESIS: To determine whether serum uric acid: (1) is associated with cardiovascular disease (CVD) death and/or all-cause mortality in type 2 diabetes; and (2) consistent with published data, predicts these outcomes in older patients and those of southern European ethnicity. METHODS: We studied those 1,268 (98%) of 1,294 type 2 participants in the observational Fremantle Diabetes Study who had a fasting serum uric acid measured at baseline. Mortality data were collected over a mean (+/-SD) 10.3 +/- 3.9 years. Cox proportional hazards modelling was used to determine independent baseline predictors of CVD and all-cause death including fasting serum uric acid as a continuous variable and quartiles. RESULTS: During follow up, 525 deaths occurred (41.4% of the cohort) of which 271 (51.6%) were attributed to CVD. In univariate analyses, patients in the highest uric acid quartile had the greatest CVD and all-cause mortality (p = 0.007 and p = 0.001). After adjustment for significant variables in the most parsimonious model, baseline serum uric acid was not an independent associate of CVD or all-cause mortality whether entered as a continuous variable (HR 1.11 [95% CI 0.96-1.27] and 1.10 [95% CI 0.98-1.22] for a 0.1 mmol/l increase, respectively) or as quartiles (p > 0.10). Analyses of 638 patients >65 years of age and 231 of southern European ethnicity produced similar results. CONCLUSIONS/INTERPRETATION: Serum uric acid was not an independent predictor of CVD or all-cause mortality in our community-based type 2 patients. Fasting serum uric acid concentrations do not appear to be prognostically useful in type 2 diabetes.
Authors:
G Ong; W A Davis; T M E Davis
Related Documents :
10941635 - In vitro and in vivo uric acid lowering by artificial cells containing microencapsulate...
6233235 - On the effect of aliphatic saturated dicarboxylic acids on anaerobic glycolysis in chic...
20053405 - Sex and age interaction with genetic association of atherogenic uric acid concentrations.
9830175 - Possibilities and limitations in miniaturized sensor design for uric acid.
18335445 - Complexation of l-lactate with boronic acids: a solution and holographic analysis.
81495 - The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator rele...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-30
Journal Detail:
Title:  Diabetologia     Volume:  53     ISSN:  1432-0428     ISO Abbreviation:  Diabetologia     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-08-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1288-94     Citation Subset:  IM    
Affiliation:
School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, P.O. Box 480, Fremantle, WA, 6959, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Cardiovascular Diseases / blood*,  epidemiology,  mortality*
Diabetes Mellitus, Type 2 / blood*,  epidemiology,  mortality*
Female
Humans
Kaplan-Meiers Estimate
Male
Middle Aged
Proportional Hazards Models
Uric Acid / blood*
Chemical
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Imported malaria in University Hospital Center of Bordeaux, France, 2000-2007. A comparison study wi...
Next Document:  Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactiv...