Document Detail


Serum uric acid and disorders of glucose metabolism: the role of glycosuria.
MedLine Citation:
PMID:  25166589     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hyperuricemia has been associated with hypertension, diabetes mellitus, and metabolic syndrome. We studied the association between hyperuricemia and glycemic status in a nonrandomized sample of primary care patients. This was a cross-sectional study of adults ≥20 years old who were members of a community-based health care program. Hyperuricemia was defined as a value >7.0 mg/dL for men and >6.0 mg/dL for women. The sample comprised 720 participants including controls (n=257) and patients who were hypertensive and euglycemic (n=118), prediabetic (n=222), or diabetic (n=123). The mean age was 42.4±12.5 years, 45% were male, and 30% were white. The prevalence of hyperuricemia increased from controls (3.9%) to euglycemic hypertension (7.6%) and prediabetic state (14.0%), with values in prediabetic patients being statistically different from controls. Overall, diabetic patients had an 11.4% prevalence of hyperuricemia, which was also statistically different from controls. Of note, diabetic subjects with glycosuria, who represented 24% of the diabetic participants, had a null prevalence of hyperuricemia, and statistically higher values for fractional excretion of uric acid, Na excretion index, and prevalence of microalbuminuria than those without glycosuria. Participants who were prediabetic or diabetic but without glycosuria had a similarly elevated prevalence of hyperuricemia. In contrast, diabetic patients with glycosuria had a null prevalence of hyperuricemia and excreted more uric acid and Na than diabetic subjects without glycosuria. The findings can be explained by enhanced proximal tubule reabsorption early in the course of dysglycemia that decreases with the ensuing glycosuria at the late stage of the disorder.
Authors:
J A M Andrade; H C Kang; S Greffin; M L Garcia Rosa; J R Lugon
Related Documents :
25315629 - Comparison of screening for gestational diabetes mellitus by oral glucose tolerance tes...
25364239 - Use of basal insulin and the associated clinical outcomes among elderly nursing home re...
10576519 - Visceral obesity and diabetes.
12489069 - Fetal nutrition and muscle oxygen supply in childhood.
14513069 - Fat oxidation, body composition and insulin sensitivity in diabetic and normoglycaemic ...
2149549 - Population study on the adipose tissue distribution in japanese women born in 1948.
21491159 - The insulin-melatonin antagonism: studies in the lew.1ar1-iddm rat (an animal model of ...
21562089 - Maternal malnutrition programs the endocrine pancreas in progeny.
3741089 - Effects of medroxyprogesterone acetate on subjective arousal, arousal to erotic stimula...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-22
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.]     Volume:  0     ISSN:  1414-431X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elevated levels of plasma osteoprotegerin are associated with all-cause mortality risk and atheroscl...
Next Document:  Relationship between deep venous thrombosis and inflammatory cytokines in postoperative patients wit...