| Serum uric acid, dehydroepiandrosterone sulphate, and apolipoprotein E genotype in benign vs. progressive multiple sclerosis. | |
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MedLine Citation:
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PMID: 15958090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The majority of patients with multiple sclerosis (MS) experience gradual progression of disability, either as secondary progressive MS (SPMS) or primary progressive MS (PPMS). A subgroup with relapsing-remitting MS shows a benign course with little or no disease progression and minimal disability decades after the first manifestations, so called benign MS (BMS). In our search to identify factors that are associated with progression of MS, we investigated serum levels of uric acid and dehydroepiandrostenedione sulphate (DHEAS), and apolipoprotein (apo)E genotype in 28 patients with BMS, 33 with SPMS, 21 with PPMS, and 29 healthy individuals. We found no significant changes in uric acid levels and apoE genotype between the four groups. Mean DHEAS levels were lower in MS patients compared with healthy controls (P = 0.049), but there were no significant differences between the clinical subgroups of MS. In patients with SPMS and PPMS there was no correlation between progression rate and serum levels of either uric acid or DHEAS. Our results suggest that serum levels of uric acid and DHEAS, and apoE genotype do not differ between patients with a benign and progressive course of MS. |
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Authors:
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G S M Ramsaransing; D J Heersema; J De Keyser |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 12 ISSN: 1351-5101 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-16 Completed Date: 2005-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 514-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital Groningen, Groningen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoproteins E / genetics* Dehydroepiandrosterone / blood* Disease Progression Female Genotype Humans Male Middle Aged Multiple Sclerosis / blood*, genetics*, pathology Uric Acid / blood* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 53-43-0/Dehydroepiandrosterone; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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