Document Detail

Serum uric acid concentrations and arthralgia among patients treated with pyrazinamide-containing regimens in Hong Kong and Singapore.
MedLine Citation:
PMID:  7314249     Owner:  NLM     Status:  MEDLINE    
The serum uric acid concentrations of patients being treated in Hong Kong and Singapore with a daily regimen consisting of streptomycin, isoniazid, rifampicin and pyrazinamide or a control regimen of daily streptomycin, p-amino-salicylic acid (PAS) and isoniazid were determined by the phosphotungstate method. Arthralgia and elevated serum uric acid levels were encountered only during the period that patients were being treated with pyrazinamide. Although daily treatment with pyrazinamide increased serum uric acid concentrations approximately 2.5-fold, the concentrations of the 6 patients who developed arthralgia were closely similar to those of matched controls without arthralgia. This fails to confirm a previous suggestion that patients with arthralgia might have higher values. Rifampicin appeared not to influence the hyperuricaemic effect of pyrazinamide.
P J Jenner; G A Ellard; W G Allan; D Singh; D J Girling; A J Nunn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tubercle     Volume:  62     ISSN:  0041-3879     ISO Abbreviation:  Tubercle     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273730     Medline TA:  Tubercle     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
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MeSH Terms
Joint Diseases / blood,  chemically induced*
Pyrazinamide / adverse effects*,  therapeutic use
Tuberculosis, Pulmonary / blood,  drug therapy*
Uric Acid / blood*
Reg. No./Substance:
69-93-2/Uric Acid; 98-96-4/Pyrazinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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