Document Detail


Serum uric acid concentration and thyroid-stimulating-hormone (TSH): results of screening for hyperuricaemia in 2359 consecutive patients with various degrees of thyroid dysfunction.
MedLine Citation:
PMID:  10378314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum uric acid concentration (sUA) and hyperthyroidism have been reported to positively correlate with each other. Furthermore, epidemiological data indicate that uric acid may be an independent risk factor for hypertension-associated morbidity and mortality. To evaluate whether screening for hyperuricaemia might be worthwhile in patients with hyperthyroidism we determined serum concentrations of uric acid in 2359 consecutive patients (1939 female, 420 male; age: 48 +/- 17 years, mean +/- SD) with various degrees of thyroid dysfunction (hyperthyroidism: n = 242; subclinical hyperthyroidism: n = 143, hypothyroidism: n = 71, subclinical hypothyroidism: n = 212) and in 1688 euthyroid subjects. No association (r = 0.03) between sUA and total T4/TSH was detected. The significant difference (p < 0.05) in serum uric acid between hyperthyroid (4.8 +/- 1.32 mg/dl) and euthyroid (4.5 +/- 1.32 mg/dl) patients was of no clinical significance. We conclude that routine determination of sUA in hyperthyroid patients is not warranted.
Authors:
W Raber; T Vukovich; H Vierhapper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  111     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-08-05     Completed Date:  1999-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  326-8     Citation Subset:  IM    
Affiliation:
Division of Endocrinology and Metabolism, University of Vienna, Austria. Wolfgang.Raber@AKH-Wien.ac.at
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Male
Middle Aged
Thyroid Diseases / blood,  physiopathology*
Thyroid Function Tests
Thyroid Gland / physiopathology
Thyrotropin / blood*
Uric Acid / blood*
Chemical
Reg. No./Substance:
69-93-2/Uric Acid; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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