Document Detail

Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease.
MedLine Citation:
PMID:  11779515     Owner:  NLM     Status:  MEDLINE    
It is a matter of controversy as to whether uric acid is an independent predictor of mortality in patients with coronary artery disease (CAD) or whether it represents only an indirect marker of adverse outcome by reflecting the association between uric acid and other cardiovascular risk factors. Therefore, we studied the influence of uric acid levels on mortality in patients with CAD. In 1,017 patients with angiographically proven CAD, classic risk factors and uric acid levels were determined at enrollment. A follow-up over a median of 2.2 years (maximum 3.1) was performed. Death from all causes was defined as an end point of the study. In CAD patients with uric acid levels <303 micromol/L (5.1 mg/dl) (lowest quartile) compared with those with uric acid levels >433 micromol/L (7.1 mg/dl) (highest quartile), the mortality rate increased from 3.4% to 17.1% (fivefold increase). After adjustment for age, both sexes demonstrated an increased risk for death with increasing uric acid levels (female patients: hazard ratio [HR] 1.30, 95% confidence intervals [CI] 1.14 to 1.49, p < or = 0.001; male patients: HR 1.39 [95% CI 1.21 to 1.59], p < or = 0.001). In multivariate Cox regression analysis performed with 12 variables that influence overall mortality-including diuretic use-elevated levels of uric acid demonstrated an independent, significant positive relation to overall mortality (HR 1.23 [95% CI 1.11 to 1.36], p <0.001) in patients with CAD. Thus, uric acid is an independent predictor of mortality in patients with CAD.
Christoph Bickel; Hans J Rupprecht; Stefan Blankenberg; Gerd Rippin; Gerd Hafner; Alexander Daunhauer; Klaus-Peter Hofmann; Jürgen Meyer
Related Documents :
1000845 - The enzymatic spectrofluorimetric determination of uric acid in microsamples of plasma ...
3707135 - Uric acid protection of nucleobases from ozone-induced degradation.
2512915 - Dynamic light-scattering studies on the effect of heat and disinfectants on spores of b...
16691645 - Evaluation of a kinetic uricase method for serum uric acid assay by predicting backgrou...
1154385 - Conformational studies of hepatitis b surface antigen (hbsag) by amino acid analysis.
15149655 - Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin c.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  89     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-07     Completed Date:  2002-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  AIM; IM    
Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Coronary Angiography
Coronary Artery Disease / blood,  mortality*
Germany / epidemiology
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Risk Factors
Survival Analysis
Uric Acid / blood*
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Usefulness of lipoprotein changes during acute coronary syndromes for predicting postdischarge lipop...
Next Document:  Relation of antibiotic use to risk of myocardial infarction in the general population.