Document Detail


Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease.
MedLine Citation:
PMID:  11779515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is a matter of controversy as to whether uric acid is an independent predictor of mortality in patients with coronary artery disease (CAD) or whether it represents only an indirect marker of adverse outcome by reflecting the association between uric acid and other cardiovascular risk factors. Therefore, we studied the influence of uric acid levels on mortality in patients with CAD. In 1,017 patients with angiographically proven CAD, classic risk factors and uric acid levels were determined at enrollment. A follow-up over a median of 2.2 years (maximum 3.1) was performed. Death from all causes was defined as an end point of the study. In CAD patients with uric acid levels <303 micromol/L (5.1 mg/dl) (lowest quartile) compared with those with uric acid levels >433 micromol/L (7.1 mg/dl) (highest quartile), the mortality rate increased from 3.4% to 17.1% (fivefold increase). After adjustment for age, both sexes demonstrated an increased risk for death with increasing uric acid levels (female patients: hazard ratio [HR] 1.30, 95% confidence intervals [CI] 1.14 to 1.49, p < or = 0.001; male patients: HR 1.39 [95% CI 1.21 to 1.59], p < or = 0.001). In multivariate Cox regression analysis performed with 12 variables that influence overall mortality-including diuretic use-elevated levels of uric acid demonstrated an independent, significant positive relation to overall mortality (HR 1.23 [95% CI 1.11 to 1.36], p <0.001) in patients with CAD. Thus, uric acid is an independent predictor of mortality in patients with CAD.
Authors:
Christoph Bickel; Hans J Rupprecht; Stefan Blankenberg; Gerd Rippin; Gerd Hafner; Alexander Daunhauer; Klaus-Peter Hofmann; Jürgen Meyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  89     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-07     Completed Date:  2002-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany. cbickel@t-online.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
Coronary Angiography
Coronary Artery Disease / blood,  mortality*
Female
Germany / epidemiology
Humans
Male
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Risk Factors
Survival Analysis
Uric Acid / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid

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