Document Detail

Serum uric acid and ambulatory blood pressure in children with primary hypertension.
MedLine Citation:
PMID:  18596575     Owner:  NLM     Status:  MEDLINE    
Hyperuricemia is associated with primary hypertension (HTN) in adults and children. Furthermore, uric acid levels during childhood are associated with blood pressure (BP) levels in adulthood. We measured 24-h ambulatory BP and serum uric acid (SUA) in 104 children referred for possible hypertension. Mean age was 13.7 +/- 2.6 y (range, 7-18 y) with 67 males and 37 females; 74 were African-American, 29 Caucasian and one Asian. SUA was associated with age (r = 0.38, p = 0.0001) and BMI Z-score (r = 0.23, p = 0.021). SUA was significantly associated with mean ambulatory systolic (S) and diastolic (D) BP. Mean ambulatory BP was normalized to gender- and height-specific reference standards using BP index. SUA was significantly associated with 24-h DBP index and nocturnal DBP index after adjusting for age, gender, race, BMI Z-score and urinary sodium excretion. SUA was also significantly associated with 24-h DBP load and nocturnal DBP load. Uric acid was significantly associated with increased likelihood for diastolic HTN (OR = 2.1, CI = 1.2, 3.7; p = 0.0063) after adjusting for other co-variables. Among children at risk for HTN, the likelihood for diastolic HTN (as defined by ambulatory blood pressure monitoring) increases significantly as SUA increases. SUA may be associated with increased severity of HTN during youth.
Deborah P Jones; Phyllis A Richey; Bruce S Alpert; Rongling Li
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  64     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2008-12-11     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-61     Citation Subset:  IM    
Departments of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA.
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MeSH Terms
African Americans
Asian Americans
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm*
Cross-Sectional Studies
European Continental Ancestry Group
Hypertension / ethnology,  metabolism*,  physiopathology*
Hyperuricemia / ethnology,  metabolism*,  physiopathology*
Uric Acid / blood*
Grant Support
000211//PHS HHS; 5K23HL83910-2/HL/NHLBI NIH HHS; K23 HL083910-03/HL/NHLBI NIH HHS
Reg. No./Substance:
69-93-2/Uric Acid

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