Document Detail

Serum uric Acid levels correlate with filling pressures in systolic heart failure.
MedLine Citation:
PMID:  21449996     Owner:  NLM     Status:  In-Data-Review    
The authors studied the relationship between liver function tests and serum uric acid level with clinical and hemodynamic profiles in heart failure. Fifty patients (aged 44±15 years; 74.5% men) with an ejection fraction (EF) <35% were enrolled and clinical assessment was performed. Hemodynamic indices (including pulmonary arterial pressure [PAP], pulmonary capillary wedge pressure [PCWP], and cardiac index were studied by standard Edwards Lifesciences Swan-Ganz catheters, and liver function tests and serum uric acid level were measured simultaneously. Fifty age- and sex-matched controls with normal EF were also studied. A total of 73% of patients had ischemic cardiomyopathy. Mean uric acid level was 7.2±3.8 mg/dL and was significantly higher than in the control group (P value<.001). In multivariate analysis, uric acid correlated significantly with PAP (r=.5, P<.001) and PCWP (r=.4, P=.002) and was also associated with clinical signs of rales, edema, paroxysmal nocturnal dyspnea (r=.5, P=.01), and New York Heart Association class (r=.4, P=.005). Uric acid level was also correlated inversely with left ventricular EF (r=.27, P=.006). Elevated uric acid levels in patients with systolic heart failure is associated with impaired clinical and hemodynamic profile and might be used as a noninvasive indicator of elevated left ventricular filling pressures. Congest Heart Fail.
Ahmad Amin; Farveh Vakilian; Majid Maleki
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Publication Detail:
Type:  Journal Article     Date:  2011-01-27
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  17     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-4     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
From the Rajaee Cardiovascular, Medical & Research Center, Heart Failure & Transplantation, Tehran, Iran.
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