Document Detail

Serum tumour necrosis factor in children suffering from Plasmodium falciparum infection in Kilifi District, Kenya.
MedLine Citation:
PMID:  7886766     Owner:  NLM     Status:  MEDLINE    
Tumour necrosis factor-alpha (TNF alpha) levels were measured by bioassay and immunoassay in sera of children infected with Plasmodium falciparum and uninfected children in the same community in Kilifi District, Kenya. Seventy-one children, mean age 2.9 years (range 4 months-6.8 years), were enrolled; 34 children had severe malaria, 23 had mild (non-severe) malaria and 14 had no malaria. TNF alpha levels were significantly elevated in children with severe malaria compared with those with non-severe malaria and the uninfected group (P < 0.001 and P < 0.00001, respectively). The levels correlated directly with parasite densities (r = 0.54, P < 0.002). Among the children with severe malaria, TNF alpha levels correlated directly with the degree of anaemia but inversely with age. High tumour necrosis factor levels were associated with manifestations of severe malaria infection but declined to normal levels after effective antimalarial treatment.
J N Nyakundi; P Warn; C Newton; J Mumo; J Jephthah-Ochola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  88     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-04-13     Completed Date:  1995-04-13     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  667-70     Citation Subset:  IM    
College of Health Sciences, University of Nairobi, Kenya.
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MeSH Terms
Age Factors
Biological Assay
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Hemoglobins / analysis
Malaria, Falciparum / blood*,  drug therapy
Parasitemia / blood
Tumor Necrosis Factor-alpha / analysis*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Hemoglobins; 0/Tumor Necrosis Factor-alpha

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