Document Detail


Serum tryptase levels in sudden infant death syndrome in forensic autopsy cases.
MedLine Citation:
PMID:  14687774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An elevated serum tryptase concentration is considered to be a specific marker for systemic mast-cell activation, a central feature of anaphylaxis, which has been observed in some cases of sudden infant death syndrome (SIDS). However, it is still unclear whether anaphylaxis is involved in the etiology for SIDS. In the present study, we measured serum tryptase levels in 21 infants with SIDS, and 14 control infants from forensic autopsy cases by Uni-CAP TRYPTASE Fluoroenzyme immunoassay system, which detects both alpha- and beta-tryptase. The assay did not show any significant elevation of tryptase levels in the SIDS group compared with controls. Additionally, increased concentrations of tryptase were not observed in any SIDS case. Our results indicated that anaphylaxis does not seem to be involved in the etiology of SIDS.
Authors:
Hajime Nishio; Koichi Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Forensic science international     Volume:  139     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
Affiliation:
Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, 569-8686, Takatsuki, Japan. leg010@art.osaka-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Autopsy
Case-Control Studies
Forensic Medicine
Humans
Immunoenzyme Techniques
Infant
Infant, Newborn
Mast Cells / enzymology
Serine Endopeptidases / blood*
Sudden Infant Death / blood*
Tryptases
Chemical
Reg. No./Substance:
EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.59/Tryptases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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