Document Detail


Serum transglutaminase in inflammatory bowel diseases.
MedLine Citation:
PMID:  1975816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the serum transglutaminase activity in patients with inflammatory bowel diseases (IBD) to correlate its level with clinical status. There were 49 patients with Crohn's disease (CD), 50 with ulcerative colitis (UC), 35 with diseases other than IBD as control group and 42 healthy subjects matched for sex and age. Enzyme activity was significantly lower in both IBD groups than in controls and in normal subjects (p less than 0.001); we found a significant negative correlation between serum transglutaminase (TG) activity and clinical severity of the disease in both IBD patient groups (r = -0.54 in CD, and r = -0.69 in UC). Moreover, in UC and CD patients, a serum TG value lower than 0.80 mU/ml retrospectively proved to predict the need for major surgery and/or total parenteral nutrition. These results suggest that serum TG may prove useful in the management of inflammatory intestinal diseases in predicting clinical outcome.
Authors:
G D'Argenio; C Cicacci; I Sorrentini; P Iovino; A Gatto; V Cosenza; G Mazzacca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  12     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-18     Completed Date:  1990-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  400-4     Citation Subset:  IM    
Affiliation:
Gastroenterology Unit 2nd School of Medicine, University of Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Colitis, Ulcerative / enzymology,  pathology,  therapy
Crohn Disease / enzymology,  pathology,  therapy
Female
Humans
Inflammatory Bowel Diseases / enzymology*,  pathology,  therapy
Male
Parenteral Nutrition
Regression Analysis
Transglutaminases / biosynthesis*
Chemical
Reg. No./Substance:
EC 2.3.2.13/Transglutaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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