Document Detail

Serum transforming growth factor-beta levels in patients with vitamin D deficiency.
MedLine Citation:
PMID:  22153539     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Transforming growth factor-beta 1 (TGF-β1) contributes to tissue repair by promoting tissue fibrosis, and elevations have been reported in patients with bone marrow fibrosis. The aim of this study was to evaluate the relationship between TGF-β1 levels and vitamin D deficiency.
METHODS: All patients presenting to the outpatient Endocrinology and Metabolic Diseases clinic between June and September of 2008 were approached, and consenting patients who were deemed suitable candidates were enrolled. Hematological parameters were measured, along with serum levels of total and ionized calcium, phosphorus, parathyroid hormone, iron, folic acid vitamin B12 levels, 25 OH vitamin D3 (25OHD(3)) and TGF-β1.
RESULTS: A total of 132 patients were included in the study. Patients were divided into 4 groups based on levels of 25OHD(3) [group 1 (<5 ng/ml), 20 patients; group 2 (5-15 ng/ml), 38 patients; group 3 (16-30 ng/ml); and group 4 (>30 ng/ml), 28 patients]. TGF-β1 levels were higher in patients in group 1 compared to the other groups. Transforming growth factor-beta levels correlated negatively with vitamin D3 and positively with leukocyte count, platelet count, of MCV and MCH. Multiple regression analyses revealed TGF-β1 levels to be associated with 25OHD(3) as well as with platelet count.
CONCLUSIONS: Results of this study are suggestive of the presence of a significant relationship between TGF-β and vitamin D deficiency. Increased TGF-β1 and platelet count may be an early indicator of bone marrow fibrosis in patients with vitamin D deficiency.
Serhat Isik; Ufuk Ozuguz; Yasemin Ates Tutuncu; Gonul Erden; Dilek Berker; Kadir Acar; Yusuf Aydin; Gulhan Akbaba; Nafiye Helvaci; Serdar Guler
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Publication Detail:
Type:  Journal Article     Date:  2011-10-24
Journal Detail:
Title:  European journal of internal medicine     Volume:  23     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-04-27     Revised Date:  2013-04-12    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.
Ministry Of Health, Ankara Numune Research and Training Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.
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MeSH Terms
Cross-Sectional Studies
Transforming Growth Factor beta / blood*
Vitamin D Deficiency / blood*
Reg. No./Substance:
0/Transforming Growth Factor beta
Comment In:
Eur J Intern Med. 2013 Apr;24(3):e47   [PMID:  23466209 ]

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