Document Detail

Serum transforming growth factor-beta 1 levels in normoalbuminuric and normotensive patients with type 2 diabetes. Effect of metformin and rosiglitazone.
MedLine Citation:
PMID:  18359746     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: a)To determine serum Transforming Growth Factor-beta 1 (TGF-beta 1) levels in patients with type 2 diabetes who do not have diabetes related complications and in healthy controls, b) to evaluate the effects of metformin and rosiglitazone on TGF-beta 1 levels. DESIGN: In the washout period, 61 patients with Fasting Plasma Glucose levels (FPG) higher than 140 mg/dl, Postprandial Glucose (PPG) levels higher than 180 mg/dl and A1c levels exceeding 6.5% were treated with glimperide. After 4 weeks, 39 of these patients were randomised to receive either metformin or rosiglitazone for 12 weeks. Thirty healthy controls were also studied. RESULTS: There were no significant differences with regard to age, gender, body weight and BMI between patients and healthy controls. Type 2 diabetics had higher waist circumference, FPG, total cholesterol, LDL-cholesterol and triglyceride levels. Baseline TGF-beta 1 levels in diabetics were higher than in controls (29.84+/-7.04 ng/ml vs 11.37+/-4.06 ng/ml, p<0.001). Metformin or rosiglitazone did not significantly modify the TGF-beta 1 levels. In a multiple regression analysis FPG was the only variable that was significantly associated with plasma TGF-beta 1 levels. CONCLUSION: The elevated levels of TGF-beta 1 in subjects with type 2 diabetes possibly indicate a tendency for renal and endothelial damage in such patients. The association of TGF-beta 1 with FPG possibly links poor diabetic control to vascular damage, leading to diabetic complications. Lack of changes in the levels of TGF-beta 1 after therapy may reflect inadequate therapy duration.
Serkan Yener; Abdurrahman Comlekci; Baris Akinci; Pinar Akan; Tevfik Demir; Firat Bayraktar; Sena Yesil
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  7     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:    2008 Jan-Mar
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  IM    
Dokuz Eylul University, Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey.
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MeSH Terms
Blood Glucose / metabolism
Blood Pressure / physiology
Body Mass Index
Diabetes Mellitus, Type 2 / blood*,  drug therapy*
Hemoglobin A, Glycosylated / analysis,  metabolism
Hypoglycemic Agents / therapeutic use*
Lipids / blood
Metformin / therapeutic use*
Middle Aged
Regression Analysis
Serum Albumin / metabolism
Thiazolidinediones / therapeutic use*
Transforming Growth Factor beta1 / blood*
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Lipids; 0/Serum Albumin; 0/Thiazolidinediones; 0/Transforming Growth Factor beta1; 122320-73-4/rosiglitazone; 657-24-9/Metformin

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